Associate Director/ Director, Data Science

Cambridge, Massachusetts
Computational Biology /
Full Time /
Flare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets for transcription factor regulation, to address mutations that cause disease. Flare’s drug discovery efforts to target switch sites has rapidly advanced, resulting in an emerging pipeline of research programs that address well-validated genetically-defined transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology and inflammation.

We are a collective of brilliant fires, trailblazing a path to conquer transcription factors and create cutting-edge medicines for patients. We embrace diversity in all its forms, experiences, and viewpoints. We are inspired by the unknown and willing to take risks. We are passionate about the science we pursue and compassionate about the patients it stands to benefit. And we respect, value, and believe in each other.

In this role you will…

    • Drive the development of Flare’s chemiproteomic engine with responsibilities to build strategic plans for next-gen analytics tools and data informatics capabilities. 
    • Catalogue reactive cysteines and their interactions.
    • Optimize analytics at identification and quantification stages.
    • Increase the probability of interaction identification through cell line optimization, proteogenomics approaches, etc.
    • Summarize and communicate results to project teams (biochemistry, mass spectrometry, biology, medicinal chemistry), provide intellectual input, and contribute to decision-making in early drug discovery.
    • Develop in collaboration with Scientific Computing the company wide strategy for data normalization and integration.
    • Identify technologies that will enable efficient data integration.
    • Drive the adoption of reproducible research platforms.
    • Design data architecture that enables data connectivity across different functions
    • Contribute to AI/ML nascent efforts as part of Flare’s overall growth strategy and mission to drug transcription factors, partnering with different functions and at various stages of early drug development. 
    • Actively contribute to defining our target prioritization for pipeline entry
    • Lead building state-of-the-art technology in target prioritization using internal and public multimodal and multi-omics data.
    • Perform exploratory analysis using data science techniques on structured and unstructured datasets and develop algorithms for early drug discovery efforts.
    • Develop or oversee the development of visualization tools that allow the data exploration of complex biological datasets.

About you…

    • You have a PhD in computational biology, bioinformatics or equivalent experience in an industry.
    • You bring previous experience with proteomics data processing and interpretation.
    • You have a minimum of 5 years’ industry experience, and ideally you have at least 3 years of early drug discovery experience.
    • You have experience with high volume drug development data (OMICs, chemical structures, etc.).
    • You also have strong knowledge of AI/ML frameworks.
    • You can demonstrate proficiency with git, Python and / or R, and other modern DevOps practices.
    • You can manage and motivate people and work done through CRO partners.
    • You may have experience with knowledge graphs and semantic web
    • You may have experience with Spotfire, Tableau or other data visualization platforms.
    • You may have experience in an oncology setting.
    • You may have experience with AWS.
    • You may also have experience with HPC and container orchestration.
    • You have had exposure to knowledge graphs/semantic web.
    • You have a track record of complex problem solving, critical thinking and leading others to achieve novel insights.
    • You have the capacity to manage ambiguity and uncertainty, within a fast growing, dynamic and risk-taking environment with resiliency, higher order multitasking skills and self-motivation.
    • You have strong communication skills, both written and verbal, especially around delivering compelling scientific narratives attuned to a particular audience.
    • You enjoy fostering a culture of innovation.
    • You love science and have a sense of humor.
Flare Therapeutics is proud to foster a diverse, equitable and inclusive company culture that embraces all people that are essential to who we are, what we do and what we believe. Flare Therapeutics is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

TO ALL AGENCIES: Please, no phone calls or emails to any employee of Flare Therapeutics about our openings. All resumes submitted by search firms/employment agencies to any employee at Flare Therapeutics via email, the internet or in any form and/or method will be deemed the sole property of Flare Therapeutics, unless such search firms/employment agencies were engaged by Flare Therapeutics for this position and a valid agreement with Flare Therapeutics is in place. In the event a candidate who was submitted outside of the Flare Therapeutics agency engagement process is hired, no fee or payment of any kind will be paid.