Director/ Senior Director, Scientific Computing & Informatics

Cambridge, Massachusetts
Informatics /
Full Time /
Flare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets for transcription factor regulation, to address mutations that cause disease. Flare’s drug discovery efforts to target switch sites has rapidly advanced, resulting in an emerging pipeline of research programs that address well-validated genetically-defined transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology and inflammation.
We are a collective of brilliant fires, trailblazing a path to conquer transcription factors and create cutting-edge medicines for patients. We embrace diversity in all its forms, experiences, and viewpoints. We are inspired by the unknown and willing to take risks. We are passionate about the science we pursue and compassionate about the patients it stands to benefit. And we respect, value, and believe in each other.

In this role you will…

    • Drive the continuous evolvement of the Flare scientific computing platform by delivering next-generation data informatics and analytics capabilities. 
    • Plan and execute complex technical projects to advance Flare scientific programs, clinical trials, and business efficiencies.
    • Summarize and communicate results and updates to internal stakeholders, provide intellectual input, and contribute to strategic planning and decision-making.
    • Coordinate production applications support and vendor communications.
    • Actively define and implement data infrastructure strategy supporting a scalable and phase-appropriate portfolio and business model.
    • Architect and drive implementation of cloud-based solutions to support state-of-the-art biotechnology workflows leveraging petabyte-scale internal and public multimodal and multi-omics data sets.
    • Deliver tools, platforms, and subject matter expertise to enable exploratory analysis using data science techniques on structured and unstructured datasets and the development of computational algorithms in support of our early drug discovery efforts.
    • Direct the development, implementation, and support of visualization tools and applications that allow exploration of complex biological datasets.
    • Develop company-wide strategies for data normalization, integration, sharing, and protection in collaboration with the Flare computational and operations teams.
    • Identify technologies that will enable efficient data integration and pipeline versioning.
    • Drive the adoption of reproducible research platforms and FAIR best practices.
    • Design architecture enabling data sharing across different functions and external partners.
    • Partner with IT and other organizations to establish and enforce data security best practices.
    • Contribute and anticipate emerging AI/ML efforts, partnering with different functions across the organization and at various stages of drug discovery and early stage development process.

About you…

    • You have a BS in engineering, computer or data science, computational biology or equivalent experience in a relevant industry.
    • You have a minimum of 10 years’ industry experience with 5+ years of cloud architecture; 3+ years supporting early stage drug discovery and/or computational environments is a plus.
    • You have deep knowledge of AWS storage, cloud computing, data transport, networking, cybersecurity, financial optimization, and identity management services.
    • You have demonstrated proficiency with Linux, git, Python, shell scripting, container orchestration, systems monitoring, automation, technical documentation, and modern DevOps best practices.
    • You may bring previous experience with relational databases, containerization, pipeline architecture, HPC, scalable batch processing, data visualization platforms, and Linux software management paradigms.
    • You may have knowledge of modern AI/ML frameworks, hybrid storage and compute technologies, reproducible computing environments, systems performance analysis, and graphs/semantic web technologies.
    • You have the ability to manage third party vendor relationships, external contracting resources, and internal project teams.
    • You have a demonstrated track record of complex problem solving, critical thinking, and clear communications, and stakeholder advocacy.  
    • You have the capacity to manage ambiguity and uncertainty within a fast growing, dynamic and risk-taking environment with resiliency, higher order multitasking skills, and self-motivation.
    • You have strong written and verbal communication skills suitable for both highly technical and general audiences.
    • You enjoy contributing to a culture of innovation on behalf of our patients.
    • You love science and have a sense of humor.
Flare Therapeutics is proud to foster a diverse, equitable and inclusive company culture that embraces all people that are essential to who we are, what we do and what we believe. Flare Therapeutics is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

TO ALL AGENCIES: Please, no phone calls or emails to any employee of Flare Therapeutics about our openings. All resumes submitted by search firms/employment agencies to any employee at Flare Therapeutics via email, the internet or in any form and/or method will be deemed the sole property of Flare Therapeutics, unless such search firms/employment agencies were engaged by Flare Therapeutics for this position and a valid agreement with Flare Therapeutics is in place. In the event a candidate who was submitted outside of the Flare Therapeutics agency engagement process is hired, no fee or payment of any kind will be paid.