Scientist I/II, Discovery
Cambridge, MA
Research /
Full-time /
On-site
Summary
GentiBio is seeking a collaborative and motivated Scientist I/II to join our Discovery team in Cambridge. The successful candidate will design, optimize and execute in vitro studies to characterize engineered T regulatory (EngTreg) cells to support our early-stage programs. This individual will leverage cellular and molecular tools to lead new target discovery for our pipelines. This role offers exposure to an organizational and company build, leadership, and an ample opportunity to be a high-impact trailblazer in the emerging field of regulatory T-cell therapy.
Responsibilities
- Responsible for engineering of CAR EngTreg cell prototypes for further characterization
- Collaborate cross-functionally to design, develop and document new assays to characterize program EngTreg Leads.
- Evaluate phenotype and functionality of CAR EngTreg constructs by a variety of assays using multicolor flow cytometry.
- Stay abreast of relevant literature and act as a resource for the team
- Contribute proactively to cross-functional activities across research groups and with other departments as needed
- Communicate and present findings to scientific team and management
- Track and compile results in an electronic notebook
- Lead from the bench, including mentoring and training junior scientists
- Foster the culture of seeking and giving help, inclusion, authenticity, and fun
Qualifications & Education
- PhD in immunology, cell biology, biological engineering, chemical engineering, or related field with 0-2 years of experience or MS with 6-8 years of relevant industry experience
- Demonstrated experience in cell culture, flow cytometry and other related immune assays such as ELISA, PCR, and cell-based assays is required
- Experience in performing immune analysis and demonstrating understanding of T cell biology, functionality and regulatory T cells is preferred. Familiarity with gene editing and delivery technologies (e.g., CRISPR and viral transduction) is strongly preferred
- Previous experience with cell-based assay development, including proliferation, suppression, and MLR assays, preferred
- Strong attention to detail and demonstrated ability to execute experiments with rigor and maintain clear and complete records of lab work
- Evidence of critical thinking and the ability to devise a plan beyond the immediate experiment.
- Proficient in Excel, PowerPoint, GraphPad Prism, Flowjo, and ELN/LIMS for data entry, analysis, and presentation
- Exceptional teamwork and communication skills with the ability to embrace change and multitask in a fast-growing environment
About us: GentiBio is an emerging biotherapeutics company co-founded by pioneers in Treg biology and synthetic immunology from Seattle Children’s Research Institute, Benaroya Research Institute, and MIGAL Galilee Research Institute. We are focused on the development of EngTregs programmed to treat autoimmune, alloimmune, autoinflammatory and allergic diseases. GentiBio’s proprietary autologous and allogeneic EngTregs platform integrates key complementary technologies needed to successfully restore immune tolerance and overcome major limitations in existing regulatory T-cell therapeutics. Our corporate operations are in both Cambridge, MA and Seattle, WA.
We are building an exceptional company culture focused on empowerment, care for one another, an appreciation for diversity and inclusion, and the development of our people. We are looking for people who are not only incredible experts in their field, but also individuals who are looking to contribute to building and modeling an outstanding company culture – and having fun while doing so
Benefits: GentiBio benefits programs are designed to promote the health and well-being of our people and their families. We offer a competitive benefits package including a choice from 3 medical plan options, dental and vision plans, flexible spending accounts (FSAs), health saving accounts (HSAs) with employer contribution, disability & life insurances, 401(k) plan with company match, unlimited PTO, parental leave for delivering and non-delivering parents, commuter subsidy, and more!
EEO Statement: GentiBio is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
Recruitment & staffing agencies: GentiBio does not accept agency resumes unless contacted directly by internal GentiBio Talent Acquisition. Please do not forward resumes to GentiBio employees or any other company location; GentiBio is not responsible for any fees related to unsolicited resumes.
