Director, Antibody Discovery and Library Design

Boston, MA /
Antibody Application Team /
/ On-site
The Institute for Protein Innovation (IPI)is a nonprofit research organization advancing protein science to accelerate research and improve human health. Founded in 2017 by Harvard Medical School professors Tim Springer and Andrew Kruse, we are located in Boston’s Longwood Medical Area.
The Institute’s three-pronged approach is to build protein tools, conduct related internal research, and develop educational programs for the protein science and broad biological research communities. With a significant endowment, IPI uniquely combines the freedom of academia with the high throughput and scale of industry to take on transformative projects. IPI has built a robust platform for discovering, developing, and distributing synthetic antibodies and other protein tools to share with the biomedical community. The Institute's deep protein expertise, collaborative spirit and research tools are powering new biomedical and therapeutic discoveries with a growing community of researchers at Harvard Medical School, Boston Children's Hospital and across Greater Boston, and beyond. 

Job Overview
The Antibody Discovery leader will play an essential role in the discovery—by display platforms— of IPI’s human synthetic antibodies, produced for a wide range of cell surface receptors and ligands. IPI’s flagship project aims to create well-characterized, high-quality antibodies—with high therapeutic and diagnostic potential—for all human cell surface receptors and their ligands. The successful candidate will be a key leader of the Antibody Discovery Team that develops antibody fragment display libraries and applies technologies to discover antibodies that bind to antigens produced by the Protein Production Team.

The individual will have proven experience in antibody library design, yeast and/or phage display, yeast (and/or phage) genetics, cell sorting and synthetic biology techniques. The Director will collaborate closely with the other Antibody Platform members and contribute to a wide array of biological discovery projects. Strong communication skills are needed to facilitate the engagement of IPI with outside collaborators to translate their biological questions into novel protein reagents, sharing them with the larger research community.

        Develop new antibody libraries for cell display to enable complementary techniques for antibody discovery
        Design and perform antibody display discovery in high-throughput approaches
        Establish standard operating protocols for cell sorting techniques to systematically obtain antibodies for a diverse range of antigens
        Produce publication-quality data analysis on sorting experiments
        Strategize how different sorting protocols may result in binders for protein complexes as well as their components
        Participate in meetings and conferences to engage and recruit outside research groups to participate in IPI’s antibody discovery activities
        Supervise research associates and interact with colleagues within the Antibody Platform to enable highly efficient antibody discovery campaigns
        PhD degree in biochemistry, molecular biology or a related field
        Experience working with display platforms for synthetic antibody discovery, including significant involvement in display library design and characterization
        Experience with sophisticated molecular biology engineering methods
        Familiarity with the kinetics of protein/protein interactions
        Enthusiastic team worker with strong engagement in tool development for the life sciences
We are committed to providing our employees with a highly competitive compensation package and outstanding benefits to support you and your family’s well-being and financial health. Highlights of our offering include:
·         100% employer-paid medical, dental, and vision plans
·         Flexible spending accounts and healthcare reimbursement accounts
·         401(k) plan with generous 6% match – immediately vested
·         Generous PTO package
·         Commuter and parking reimbursement
·         Educational assistance  
·         Career development opportunities
For more information, visit or follow us on social media, @ipiproteins.
IPI is an independent 501(c)(3) nonprofit research organization and an equal-opportunity employer. The Institute celebrates diversity and is committed to creating an inclusive environment for all employees.

IPI does not accept unsolicited resumes from third party recruitment firms.