Research Associate II/Senior Research Associate I, Protein Science

South San Francisco
Biologics /
Full-Time /
Lycia Therapeutics, Inc. is a biotechnology company leveraging its lysosomal targeting chimera (LYTAC) platform from Founder and Chemistry Nobel Laureate 2022, Carolyn Bertozzi, to discover and develop first-in-class therapeutics that degrade extracellular and membrane-bound proteins. Lycia’s next generation degraders harness the cell’s endogenous lysosomal trafficking and degradation machinery with the potential to degrade targets previously considered to be intractable, across a spectrum of indications. After raising $105 million in capital in 2021, Lycia is advancing an internal pipeline of novel degraders and has entered a strategic collaboration with Eli Lilly to address key unmet medical needs. In May 2024, Lycia Therapeutics completed a $106.6 million series C financing to advance its pipeline of LYTAC extracellular protein degraders to the clinic. Lycia is headquartered in South San Francisco. 

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The Role:
We are seeking a highly motivated Research Associate II/Senior Research Associate with Protein Science experience to join our team. The ideal candidate should have a Bachelor's or Master's degree in a relevant field, with 2+ years of research experience, preferably in an industrial setting. The primary responsibility of this role is to perform protein conjugation to support discovery and pipeline programs. Prior protein conjugation experience is desirable but not required for this position. We are happy to train the right candidate who has experience in protein purification and protein chemistry.


    • Perform conjugation of proteins following established protocols and procedures.
    • Conduct protein purification utilizing various chromatographic techniques.
    • Perform analytical characterization of proteins and bioconjugates.
    • Maintain accurate records of experiments, results, and observations.
    • Adhere to safety guidelines and protocols in the laboratory environment


    • Bachelor's or Master's degree with 2+ years of research experience. Experience in the industry is preferred.
    • Degree in Biochemistry or related discipline.
    • Strong understanding of protein chemistry and bioconjugation techniques.
    • Experience with protein conjugation and/or purification.
    • Some experience with analytical techniques such as HPLC, CE-SDS or mass spectrometry is desired but not required.
    • Strong communication skills and a willingness to assist team members when needed.
    • Excellent organizational skills and attention to detail.
    • Ability to work both independently and collaboratively in a fast-paced environment.
$85,000 - $120,000 a year
The expected base salary range for this role is $85-100k for Research Associate II and $98-120k for Senior Research Associate I. We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications and internal equity. Lycia offers a competitive employment package that includes an annual bonus, equity, and a generous benefits package.
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status