Director, Computational Chemistry

Fully Remote /
Drug Discovery /
Full Time
/ Remote
Company Overview
Plexium is a pharmaceutical company focused on developing first-in-class protein degrader therapeutics that go beyond the limitations of bivalent degraders and cereblon molecular glues. Our novel integrated drug discovery platform consists of state-of-the-art medicinal chemistry and DNA-encoded library technologies, ultra-high throughput cell-based screening, deep biological understanding of protein degradation, and extensive proteomics and informatics capabilities.  Our integrated platform allows us to discover and develop novel degraders of therapeutically validated proteins for cancer and other important disease areas.

Plexium has a positive, friendly, and collaborative work environment with a culture that values teamwork, initiative, ownership and thoughtful risk-taking in developing innovative solutions to challenging scientific problems. We are committed to fostering innovation at all levels, cross-functional team collaboration, and supporting the growth and development of our team members.  

Position Summary
The successful candidate will be an expert in applying modern computational (structure- & ligand-based design, MD etc.) and cheminformatics (data mining and visualization) tools to small molecule drug discovery projects. The candidate will lead or be a member of project teams and will be recognized as an expert contributor of modern computational chemistry. Key interactions will be with project teams and especially with medicinal and library chemists, drug discovery leadership, informatics and IT. 

Essential Job Responsibilities

    • Expertly apply SBDD, molecular modeling and dynamics, 3D QSAR and other tools to support internal drug discovery projects from idea to clinical candidate selection
    • Support new target selection with structural analysis and application of state-of-the-art computational tools
    • Conduct library design with state-of-the-art computational tools, including library enumeration and property computation
    • Perform virtual screening and ensure that virtual libraries maintain drug likeness
    • Provide computational ADME/Tox support for lead discovery and hit-to-lead programs
    • Provide educational support in good medicinal chemical practices and train the Plexium scientific community in the best use of visualization and enumeration tools and their proper interpretation

Education and Experience Requirements

    • PhD in Chemistry or a related field
    • Minimum of 12 years’ experience in small molecule drug discovery

Skills and Knowledge

    • Expert with modern computational chemistry software such as Schrodinger, MOE, Pipeline Pilot, KNIME, and Rosetta
    • Good knowledge of computational techniques to structural and ADME/Tox problems in support of both lead discovery and lead optimization
    • Good knowledge of chemoinformatics tools and use of such for data mining and data visualization
    • Knowledge of the targeted protein degradation field is preferred
    • Excellent scientific problem-solving skills and a track record of bringing forward successful innovative solutions to chemistry problems
    • Excellent communication and collaboration skills, and embrace working as part of a multi-disciplinary teams in a fast-paced, innovative drug discovery environment, working to project priorities and deadlines
The US base salary range for this full-time position is $200,000-$250,000 + target annual bonus + equity + health and well-being benefits. Our salary ranges are determined by a number of factors, including but not limited to the role, location, job-related skills, and relevant education, experience and training. The range displayed on each job posting reflects the minimum and maximum target for new hire base salaries for the position across all US locations and vary by the location of the position. Our Talent Acquisition Team can share more about our salary ranges and other benefits of working at Plexium, which are not included in the posted base salary range.

Notice to third party recruitment agencies: Plexium does not accept unsolicited resumes from recruiters or employment agencies. In the absence of an executed recruitment services agreement, there will be no obligation to any referral compensation or recruiter fee.

In the event a recruiter or agency submits a resume or candidate without an agreement Plexium shall explicitly reserve the right to pursue and hire those candidate(s) without any financial obligation to the recruiter or agency. Any unsolicited resumes, including those submitted to hiring managers, shall be deemed the property of Plexium.