Senior Pilot Plant Associate, Process Development (Contract)
Redwood City, CA
Technology Development – Process Development /
Contract /
On-site
Adverum is looking for a Senior Pilot Plant Associate to join our Process Development team in Redwood City. This individual will be a key member of the team, focusing on downstream activities.
This is a 6 month contract with an opportunity for an extension.
What you'll do:
- Perform pilot scale downstream purification process and manufacturing (post cell lysate to final formulation) by utilizing column chromatography, CsCl, UFDF, and various filtration steps.
- Follow good documentation practices to maintain accurate records.
- Work closely with team members to perform buffer preparation.
- Set-up, operate and maintain required downstream laboratory equipment.
- Maintain reagent, sample, and consumables inventory.
- Assist with data entry and data analysis in Excel and/or other statistical programs.
- Work closely with the downstream team to perform downstream experiments.
- Ensure safe workplace in compliance with the company and EHS' rules and regulations.
- Work with Assay Development and Quality Control to coordinate testing.
- Work to identify optimize, revise, and update current process batch records, protocols, and procedures to make them more robust and streamlined.
About you:
- Requires a Bachelor’s degree (or higher) in chemical/biochemical engineering or related fields with 4+ years of downstream purification experience.
- Proficient in general and non-routine laboratory skills including aseptic technique, multi-channel pipetting and biosafety cabinet operations.
- Hands on experience with buffer preparations, TFF (Hollow Fiber/Cassettes), UF/DF and Column Chromatography Purification. Experience working with AKTA Avant is required.
- Requires some knowledge of GxP standards, and the ability to apply compliance principles to Adverum’s laboratory practices.
- Able to work in a fast-paced environment as a team player with effective communication skills.
- Excellent computer skills; especially proficient in Excel and Word.
- Strong desire to learn new technologies, skill sets, and the science behind AAV processing.
- Strong teamwork and communication skills.
- Some overtime required, as needed.
