Vice President Drug Discovery

South San Francisco, CA
Biology /
Full-time /
Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history 

We are seeking an inspirational and transformational Biology leader to lead and move forward our pre-clinical programs efficiently. Your extensive experience and expertise in Neuroscience drug development will play a pivotal role in shaping the future of our research endeavors! Core areas of focus will be to translate genetics and human biology into both in vitro (IPSC cellular models) and in vivo systems (mouse models) to understand innate immune modifiers of the pathogenesis of neurodegenerative diseases. We strive to dissect the molecular, cellular, and tissue-level mechanisms by which genetic variants modulate disease risk, with a major focus on the role of microglial cell function in vitro and in vivo.

You will be reporting to our Chief Scientific Officer & Head of Research, and you will manage a team of research biologists and project team leaders and work across teams including Antibody and Protein Engineering, Nonclinical sciences, Tech Ops, and CMC.

In your first year, you will:

    • Set strategy for our research areas and maintain strategic focus across multiple complex drug discovery programs, prioritize resource allocation, and drive decisions consistent with company goals. Ensure the timely execution of our project portfolio with strong scientific plans and data generation.
    • Work closely with our CSO to incorporate new ideas and translate them with the team into programs. Provide scientific, strategic, and mentorship to an enthusiastic team of scientists.
    • Maintain an excellent grasp on emerging areas of immunology and neuroscience research that are potential competitive advantages, including engaging in external collaborations in support of our discovery and development programs.
    • Collaborate with your business partners to devise comprehensive strategies that use innovative technologies.
    • Seamlessly integrate discovered targets into preclinical plans enabling well-informed decision-making throughout the preclinical phase.


    • Ph.D. in Immunology or Neuroscience with over 20 years in academia or in the biotech/pharmaceutical industry, including 10+ years in drug discovery.
    • Expertise and scientific achievement in Immunology/Neuroscience related neurodegenerative disorders.
    • Deep experience leading drug discovery programs to the IND stage
    • Highly proficient with all facets of drug discovery and ability to collaborate with peers in other departments to ensure project advancement.
    • Excellent people leader and mentor
    • Ability to design and execute translatable proof of concept studies.
    • Expertise in in vivo studies in rodents.
    • Proactive, innovative, with good problem-solving skills
    • Ability to work in a cross-functional team and matrix environment.
    • Ability to influence peers, colleagues, and senior leadership

At Alector, our vision is bold, people are our priority, and our values are at the core of everything we do. Our dynamic and flexible environment encourages our teams to experiment, take ownership of decisions, and question convention to solve complex problems. We value shared wins, perseverance, and a growth mindset, which drives us forward, together.  

Among the things you'll discover at Alector from your very first day are our committed and driven colleagues, a bold company vision, and new, modern offices designed to inspire innovation and collaboration in South San Francisco, right at the heart of Biotech Bay. Our benefits are thoughtfully designed around Alectorians and their loved ones and include flexible hybrid work options, competitive compensation, and comprehensive and unique benefits that enhance your health and well-being. Come join us! 
We believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.  

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation. 

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