Vice President, Discovery Research

Seattle, WA Hybrid
Research – Leadership /
Full time /
Alpine Immune Sciences is a leading clinical-stage biopharmaceutical company dedicated to discovering and developing innovative, protein-based immunotherapies for autoimmune and inflammatory diseases. Exciting challenges lie ahead—guided by our core values, we’ll meet these challenges. Join us!

The Vice President, Discovery Research will oversee Alpine’s discovery research organization and provide leadership across discovery, preclinical and clinical research. Contributes to pipeline prioritization, planning, strategy, and implementation of R&D plans.

Duties and responsibilities

•Drive innovation through a deep understanding of immunology and creative application of novel technologies and develop a robust and high-quality product portfolio. 
•Establish and execute upon a strategic research plan, targeting new initiatives in immunotherapy while supporting existing development programs
•Oversee all discovery projects and scientific operations to ensure the organization meets its scientific objectives, in pursuit of new disease indications and target opportunities
•Lead discovery initiatives including protein engineering, in vitro and in vivo pharmacology
•Collaborate with Translational Medicine and Clinical Development to evaluate potential biomarkers and identify target indications
•Set clear expectations, give appropriate autonomy, and guide team members; manage performance by providing feedback, guidance/teaching, and development opportunities
•Lead and manage the development of annual scientific goals, including obtaining and acting upon inputs from the Board of Directors, the Scientific Advisory Board, and collaborators.
•Establish and effectively manage industrial and academic collaborations and internal/external partners.
•Ensure up ¬to ¬date knowledge of developments in discovery research and practices, and timely dissemination of this knowledge.


•PhD in immunology or related field with a minimum of 15 years of relevant proven experience in drug development, including demonstrated success at the conception, discovery and development of first-in-human drug development candidates (e.g. successful INDs or equivalents)
•Self-starter with strong scientific curiosity and rigor, excellent interpersonal and analytic skills, high ethical standards, and outstanding written and verbal communication skills.
•A desire to be part of a highly innovative, dynamic, and growing company aimed at developing novel therapeutics for patients.
•Demonstrable ability and enthusiasm for identifying, setting, and meeting ¬critical deliverables, delivering clinical candidates into development.
•Track record of developing efficient discovery processes and leading complex cross-functional team collaborations, including managing relationships with internal and external collaborators.
•Proven track record of advancing programs through discovery, IND-enabling studies, and IND filing.
•Ability to build strong relationships with key stakeholders.
•Ability to celebrate differences and encourage scientific openness and frank discussion.
•Team¬ oriented and invests in the success of others.
•Ability to travel domestically and internationally.

At Alpine we engage equitable workplace strategies to ensure fair compensation. Actual compensation is dependent upon current market data, experience, and pay parity within our organization. This position is a Vice President level position, with a compensation range of $288,000 - $321,000. In order to be considered for a position, candidates must be located in one of the following five states: CA, MA, NC, OR, or WA. We take care of our employees with a competitive benefits package that includes stock options, annual bonus, premium medical, dental, and vision coverage for employees and their dependents, as well as life and disability benefits, FSA, and 401(k) plans. We believe quality time outside the office is vital to our employees’ satisfaction at work, so our flexible PTO plan of 160 hours, generous holiday time (generally 12 days), and parental benefits encourages team members to take time off so they can come back refreshed. Alpine team members enjoy competitive salaries and equity participation (stock options).

Alpinists share a passion for meaningful work and are committed to solving the most complex problems in immunology to create new therapies for patients. We believe in innovative thinking, collaboration, flexibility, bias for action, and healthy debate. To foster our team of outstanding scientists and business professionals, we provide a premier work environment with a state-of-the-art lab and office spaces with truly inspiring views, and an open design to facilitate teamwork.

Our treasured culture has been shaped by our diverse team who truly enjoys working and playing together. We nurture Alpine’s culture in many ways, including all-company social events and happy hours, lunch-and-learn and education opportunities, interest groups like book club and movie nights, peer-to-peer recognition programs, a robust wellness program to help support physical, mental, and emotional health, and more.

Alpine is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. Alpine is also committed to compliance with all fair employment practices regarding citizenship and immigration status.

Our office and lab are located in the blossoming biotech neighborhood of Eastlake in Seattle. Alpinists enjoy the flexibility to work onsite, remotely, or a hybrid schedule, with evolving options as we prioritize keeping Alpinists safe and healthy. Onsite employees enjoy an open-office layout with comfortable huddle rooms and Zoom Room-enabled conference rooms, a spacious breakroom and kitchen with a coffee bar and snacks, and rooftop access to enjoy gorgeous views of Lake Union and Gas Works Park.

Exciting challenges lie ahead—guided by our core values, we’ll meet these challenges.  Join us!