Associate Director/Director, Clinical Science

Clinical Development – Clinical Science /
Full time /
Alpine Immune Sciences is a leading clinical-stage biopharmaceutical company dedicated to discovering and developing innovative, protein-based immunotherapies for autoimmune and inflammatory diseases. Exciting challenges lie ahead—guided by our core values, we’ll meet these challenges. Join us!

The Associate Director or Director of Clinical Development is responsible for supporting the design, execution, analysis, interpretation, and presentation of clinical studies. Supports and may participate in the development and execution of strategies for new product development and lifecycle growth, including regulatory and investigator interactions as applicable.
Duties and responsibilities:
Provides clinical strategic input for clinical and translational projects.
Supports the planning, organization, and direction of the activities of clinical trials, including development of clinical protocols and amendments, investigator brochures, and clinical study reports.
Participates in medical monitoring support, including evaluation of safety, pharmacology, and efficacy of ongoing and completed studies.
Assists with the establishment and implementation of exploratory pharmacodynamic, diagnostic, and biomarker plans in conjunction with partners in clinical pharmacology and diagnostics/biomarkers.
May interact with external thought leaders, including advisory boards, to support clinical and translational development.
May prepare or participate in literature reviews and publications as appropriate.
PhD with experience or specialization in an immunology field.
At least 5-7 years clinical scientist experience is preferred, particularly in drug development.
Ability to communicate efficiently with preclinical, biomarker, biostatistical and computational scientists, as well as clinical and commercial colleagues who may be outsourced and/or remote. Ability to explain medical and scientific technical issues to technical and non-technical staff.
Proven experience implementing and conducting clinical trials.
Demonstrated ability to develop and maintain excellent working relationships with both internal colleagues and external contacts, including key thought leaders, and investigators.
Demonstrated ability to work well in teams in a cross functional manner.
Ability to communicate and work independently with scientific/technical personnel with excellent oral presentation skills.
Ability to think critically and demonstrated troubleshooting and problem-solving skills.
Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities.

At Alpine we engage equitable workplace strategies to ensure fair compensation. Actual compensation is dependent upon current market data, experience, and pay parity within our organization. This position is an Associate Director level position up to a Director level, with a compensation range of $210,000 - $240,000 for an Associate Director, and $220,000 - $250,000 for a DirectorNote that there is a strong preference for candidates to be located in one of the following five states: CA, MA, NC, OR, or WA. We take care of our employees with a competitive benefits package that includes stock options, annual bonus, premium medical, dental, and vision coverage for employees and their dependents, as well as life and disability benefits, FSA, and 401(k) plans. We believe quality time outside the office is vital to our employees’ satisfaction at work, so our flexible PTO plan of 160 hours, generous holiday time (generally 12 days), and parental benefits encourages team members to take time off so they can come back refreshed. Alpine team members enjoy competitive salaries and equity participation (stock options).

Alpinists share a passion for meaningful work and are committed to solving the most complex problems in immunology to create new therapies for patients. We believe in innovative thinking, collaboration, flexibility, bias for action, and healthy debate. To foster our team of outstanding scientists and business professionals, we provide a premier work environment with a state-of-the-art lab and office spaces with truly inspiring views, and an open design to facilitate teamwork.

Our treasured culture has been shaped by our diverse team who truly enjoys working and playing together. We nurture Alpine’s culture in many ways, including all-company social events and happy hours, lunch-and-learn and education opportunities, interest groups like book club and movie nights, peer-to-peer recognition programs, a robust wellness program to help support physical, mental, and emotional health, and more.

Alpine is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. Alpine is also committed to compliance with all fair employment practices regarding citizenship and immigration status.

Our office and lab are located in the blossoming biotech neighborhood of Eastlake in Seattle. Alpinists enjoy the flexibility to work onsite, remotely, or a hybrid schedule, with evolving options as we prioritize keeping Alpinists safe and healthy. Onsite employees enjoy an open-office layout with comfortable huddle rooms and Zoom Room-enabled conference rooms, a spacious breakroom and kitchen with a coffee bar and snacks, and rooftop access to enjoy gorgeous views of Lake Union and Gas Works Park.

Exciting challenges lie ahead—guided by our core values, we’ll meet these challenges.  Join us!