Senior Medicinal Chemist

Paris /
Drug hunter /
Full-time (French "CDI")
/ Hybrid
At Aqemia you will work in a multi-disciplinary team of passionate drug hunters, AI engineers and developers who are committed to our mission of finding many drugs, at high pace, to cure diseases.

As part of our growing team, you will enjoy a fast-paced, challenging, science-driven and creative environment, working at the very forefront of AI & Deep physics-powered drug discovery. This is a tremendous opportunity to bring your own impact on changing the way medicines are discovered and be involved in shaping the direction of our fast growing business and team.

We are looking for highly skilled and collaborative individuals who are naturally curious, have a passion for learning and solving complex problems with a “can-do” mindset.

If this sounds exciting to you, come and join us!

The difference you’ll make

Within Aqemia’s drug discovery portfolio team, Medicinal Chemists play a key role in our drug discovery projects.

Objective of such projects is to invent therapeutic molecules (hits / leads) against a given target protein and related disease, leveraging our unique technology combining new Physics and Machine Learning algorithms. Projects can be in collaboration with pharmaceutical companies to invent molecules for their targets, or within Aqemia internal project portfolio.

A project is run by a core team - ie a drug hunter, a project leader, plus part of a Chemist and Biologist - and relies on the technology and ways of working developed by Aqemia platform.

What you'll do

    • Challenge de novo designs by the Aqemia technology and propose designs to optimize compounds especially from a synthesis and drug-likeness point of view.
    • Give systematic feedback to Aqemia’s technology platform in a structured and constructive way, based on your experience and project experimental results
    • Challenge the CROs on the synthetic routes and experimental results. 
    • Propose alternative solutions to ensure a good throughput for delivery of final products
    • Proactively partner cross-functionally to address specific project needs 
    • Mentor more junior drug hunters or Chemists

Your profile

    • You have Ph.D. and post-doctoral experience as well as a track record of technical excellence as shown by peer-reviewed publications
    • You have 5+ years of pharma/biotech/CRO experience with a focus on medicinal chemistry.
    • Inventorship status on patents is a great nice to have
    • You have an outstanding track record in synthetic chemistry of small molecules and medicinal chemistry in biotechs, CRO or pharma companies.
    • You are used to use computational tools and visualization, though coding is not required

Who you are

    • You are eager to play an active role in contributing to Aqemia’s strategy to develop drugs for patients.
    • You are anxious to bring your wealth of knowledge and skills to the table to inspire and coach brilliant people from diverse backgrounds.
    • You are keen to solve tough problems on issues that truly matter.
    • You are inquisitive, and proactive with a can-do attitude.
    • You are excited to join a small team and make your mark on drug discovery.
    • You thrive on working collaboratively in a fast-paced, interdisciplinary environment that keeps everyone on track.
Our Workplace Environment
• Fast-paced, intellectually and scientifically demanding, results-driven.
• Our Founders boast : 10+ years experience in research at Ecole Normale Supérieure in Paris, not to mention a stint in Oxford and Cambridge / 10+ years experience in strategy consulting at BCG.
• Aqemia has a rapidly growing team of +50 people from world-class institutions (AstraZeneca, GSK, Sanofi, Harvard, Ecole Normale Supérieure, Ecole Polytechnique, BCG)
• Our premises are conveniently located in the center of Paris (1 Bd Pasteur), with a possibility of up to 2 days of remote work.
• We are part of the French Tech 2030 program (
• Working language: English

We are growing fast, if you feel that you don't fit this job description but you’re still excited to join, then please get in touch! 
Aqemia is an Equal Employment Opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion or belief, sex, sexual orientation, gender perception or identity, national origin, age, marital status, disability status or any other basis under applicable law.