Discovery Scientist, Biochemistry

San Francisco Bay Area /
Active Search /
Full time
This posting is for an active search. At Arcadia, an active search (as opposed to an “open search”) means we have a clearly-defined need and are actively looking to fill this position in the next 2-3 months. We intend to move relatively quickly once we find the right candidate.

A Bit About Us
We are Arcadia Science. Arcadia is a well-funded, for-profit biology research and development company founded and led by scientists. Our mission is to give a community of researchers the freedom and tools to be adventurous, to discover, and to make scientific exploration financially self-sustaining in the life sciences. We are inspired by the spirit of exploration and aspire to evolve how science is done, who it attracts and rewards, and what it can achieve.

The Opportunity:
We are seeking an experienced biochemist to join a collaborative team of cell biologists aiming to understand cellular function across the tree of life. We are focused on unusual organisms with unique characteristics, including algae with divergent protein homologs, protists that survive in harsh environments, and Archaea with eukaryotic-like cellular components. We are looking for someone with a strong background in protein biochemistry, protein engineering and purification, and quantitative biochemical and chemical assay development to join the team.
As a bench scientist, you will work closely with the cell biologists at Arcadia, contributing to ongoing projects focused on the cytoskeleton, cell motility, and cellular encystment. This will require expertise in purifying proteins and protein complexes (ex. cytoskeletal proteins) and carrying out functional assays (ex. binding and polymerization assays). For this work, you will contribute to discussions about protein function and structure, design and optimize recombinant protein production, and develop and evaluate assays. All Arcadia scientists have the opportunity to pitch their own projects as well.

Our ideal candidate:
We are looking for someone with:
****Significant research experience (preferably 4+ years) with a background in protein engineering/biochemistry
****Direct hands-on experience reconstituting complex biochemical pathways in vitro
Direct hands-on experience purifying native complexes from complex in vivo mixtures
****Experience carrying out or managing collaborations for standard chemical and biochemical analytical methods, such as HPLC, FPLC, protein electrophoresis and ELISAs, LC/MS, pull-downs, etc.
Experience producing and purifying recombinant proteins across a wide range of expression systems, such as bacteria, yeast, and insect cells, and potentially purifying native proteins and protein complexes from diverse organisms (ex. fungi, algae*,* etc.)
A commitment to sharing scientific processes and results openly and in a timely manner
In addition, you should be well-organized and able to troubleshoot independently. Given that we are exploring new biochemical pathways, you should have demonstrable experience exploring creative out-of-the-box solutions for expressing difficult proteins or establishing new assays. You should have experience thinking about biochemical mechanisms underlying complex biological processes, you should enjoy the trial-and-error nature of exploring new biology and setting assays up for the first time, and you should be comfortable taking risks. Most importantly, you should be highly collaborative, and excited to work as part of a highly focused, interdisciplinary team to dig deep into the biochemistry of unusual cellular processes!
At Arcadia, we strive to maximize the utility of our work through early sharing of reusable data/tools or through translation of discoveries. A successful candidate can expect to be compensated between $125,000-175,000/year with benefits and a highly competitive equity offering, depending on experience level. This is a full-time on-site position.

Application process:
Interested candidates should apply using the link below and include a cover letter and a brief response to the following questions (no more than the equivalent of ½ page total).
Which recombinant protein expression systems do you have direct experience with? Do you have any experience purifying untagged, native proteins?
Describe the most challenging/frustrating biochemical effort you have ever had to troubleshoot and how did you overcome the challenge.
And finally, can you explain actions you’ve taken that might be aligned with our open science mission.
Applications will be reviewed on a rolling basis, and the job will remain open until the position is filled. Arcadia Science is an equal opportunity workplace; we welcome people from all backgrounds and communities. We provide competitive compensation and practical benefits to keep you happy and healthy so that you can do your best work.