Senior Research Associate I, Cell Isolation/Genome Engineering (22043-U-675-ATA)
Hybrid
Discovery /
Full-Time /
On-site
We are seeking a talented and motivated Research or Senior Research Associate to support the ArsenalBio Discovery team. The individual will be responsible for participating in the development and execution of automated T cell isolation, genome engineering, and cell expansion processes and procedures that enable downstream workflows company-wide. This candidate will also be responsible for R&D efforts focused on optimizing and further improving Arsenal’s genome engineering workflows in primary human T cells using our proprietary non-viral engineering technology. The ideal candidate will have experience with mammalian cell culture, experience isolating primary human cells, experience performing flow cytometry, an understanding of CRISPR-Cas9 based cell engineering methods, and experience running laboratory automation including liquid handlers. This position will report to the Lead of the Arsenal T cell Armory (ATA) within the Pre-Clinical Pharmacology group. The individual will also be a major part of expanding the core and research functionality of the ATA with cross-functional interactions with the Pre-Clinical Development, Immunology, Synthetic Biology, Process Development and Analytical Development teams, as well as across the organization to enable ArsenalBio’s success.
What You Will Do:
- Work within the team to enable the core functionality of cell isolation and genome engineering workflows
- Design and execute genome engineering studies to generate edited primary cells using both manual and automated methods.
- Perform automated isolation of primary human T cells starting from enriched apheresis product
- Act as a point person to identify the needs of the organization with respect to fresh primary human T cells and genome engineering services and ensure these needs are met.
- Coordinate and integrate multiple different workflows into the cell isolation and genome engineering core activities.
- Perform characterization of both isolated and gene modified T cell populations
- Assist in the development and optimization of the cell processing platform
- Perform troubleshooting and testing of experimental workflows
- Keep detailed logs of studies to contribute to the dissemination of results
- Support and maintain reagent inventory, instrument maintenance, SOP writing, and related administrative tasks
What Will You Bring:
- Bachelors in cell, molecular, immunological, or genomic basis of human diseases
- Masters in cell, molecular, immunological, or genomic basis of human disease with 0-2 years of research experience involving primary T cell culture and isolation; or Bachelors degree and 2+ years experience.
- Experience in cell processing ideally with systems such as the Miltenyi MultiMACS, Miltenyi MACS magnetic separation, Stemcell Technologies Easysep/Robosep, and equivalent platforms
- Experience with targeted gene editing workflows including CRISPR-Cas9 technology
- Experience developing multi-color flow cytometry panels and performing flow-based analysis on primary human cells
- Experience with automation platforms, specifically Hamilton automated liquid handlers
- Proficiency in basic molecular biology laboratory techniques, pipetting, PCR, and flow cytometry
- Excellent written and verbal communication skills and proficiency in GSuite
- Ability to quickly learn new skills and knowledge on the job, demonstrate productivity, and deliver high-quality results
What We Will Offer You:
ArsenalBio has a generous and comprehensive benefits package that includes but is not limited to medical, dental, and vision as well as mental health resources, virtual and telehealth options, coaching, infertility treatment, parental leave and health savings accounts. We also offer flexible work schedules and flexible time off, which includes two extra “Arsenal Days of Rest” every quarter for employees to recharge.
We have a robust mentorship program, and comprehensive development tools to help employees take control of their career paths and grow into their best selves. ArsenalBio believes in investing in the well-being of our employees - both at work and at home, as they are our greatest asset. They bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.
