Scientist I - In Vivo Translation (24122-R-675-PCP)
South San Francisco
Discovery /
Full-Time /
On-site
WHO WE ARE
ArsenalBio, a privately held, clinical-stage programmable cell therapy company engineering advanced CAR T therapies for solid tumors, is seeking a talented on-site Scientist I to be a part of our preclinical In Vivo Translation team based in our South San Francisco office.
ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer. With our programmable and computationally driven approach, our team is engineering living medicines to attack cancer’s inherent multifaceted nature and overcome the challenges of addressing solid tumors with cell therapy.
Driven by a collective of diverse experts across multi-scientific disciplines as well as clinical and manufacturing expertise, we are united in our purpose to develop the optimal medicines for improving patients’ lives.
This means you’ll have the opportunity to work with the best talent in the field of cell therapy, and be part of ONE TEAM advancing therapies for patients who need it most.
We are looking for a highly motivated Scientist I to support preclinical in vivo pharmacology and translational sciences within the Pre-Clinical Pharmacology group at ArsenalBio. Reporting to a Principal Scientist, the successful candidate will work with cross-functional teams to design and conduct key in vivo studies and communicate experimental data to support the progress of multiple internal and external collaboration research programs. This role requires an individual with outstanding self-initiative, data analysis, and communication skills.
WHAT YOU WILL DO
- Support the preclinical In Vivo Translation team utilizing tumor xenograft and syngeneic mouse models for discovery and IND-enabling studies for CAR-T adoptive cell therapy.
- Role involves design and execution of in vivo studies, as well as model development to support mechanistic and discovery science as well as pharmacology efforts to advance projects as required.
- Execute hands-on responsibilities including, but not limited to animal handling and restraint, administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice, including health checks and documentation, will also be required.
- Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status; investigate adverse study events. Meticulous electronic lab notebook documentation.
- With minimal guidance, collect, analyze, interpret, and present data within the Pre-clinical Pharmacology group and across functional areas within the company.
- Desgin and perform rodent dosing studies, in vivo candidate selection studies, blood and tissue sampling, flow-cytometry based PK and immune cell phenotyping analysis, surgeries and isolation of tumor infiltrating CAR-T cells for mechanism of action as required.
- Execute ex vivo techniques such as tissue dissociation, flow cytometry, Luminex/ELISA is highly preferred.
- Communicate experimental plans and results to the leadership team. Support product development and regulatory filings for pivotal clinical studies.
WHO YOU ARE
- Masters with 5+ years experience, or Bachelor with 7+ years experience in a biotechnology/pharmaceutical company.
- Strong background in tumor biology, immunology, and in vivo tumor model development including human xenograft models and development of novel models to elucidate and characterize drug mechanisms of action.
- Extensive hands-on experience with all aspects of running tumor models, including experience working with immune-oncology antibodies, small molecules, or cancer adoptive cell therapy is highly desired.
- Experience with aseptic cell culture of mammalian cell lines with additional weight given for CAR-T cells.
- Extensive experience in establishing mouse tumor models in immune competent and compromised animals.
- Proficiency in drug administration (SQ, IP, IV, and PO), blood collection routes (Sub-M and others) and full body necropsy.
- Experience in diverse ex-vivo assays including flow-cytometry and tissue collection and downstream processing including for gene-expression and/or protein assays (luminex, ELISA).
- Software experience in Excel, Google suite, Prism, Powerpoint, electronic lab notebooks, and in vivo data management platforms.
- Demonstrated ability to work collaboratively in a cross-functional environment.
- Ability to follow instructions and work independently and to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines.
- Must have excellent troubleshooting, organization, and planning skills, and the ability to work under timeline in a fast-paced environment.
- Excellent written and oral communication skills to effectively share scientific findings.
- Excellent documentation skills including maintenance of daily records using Electronic Lab Notebooks and generation/maintenance of SOPs.
BENEFITS AND PAY
ArsenalBio has a generous and comprehensive benefits package that includes but is not limited to medical, dental, and vision as well as mental health resources, virtual and telehealth options, coaching, infertility treatment, parental leave and health savings accounts. We also offer flexible work schedules and flexible time off, which includes two extra “Arsenal Days of Rest” every quarter for employees to recharge.
Our people-first culture cultivates a deep respect for humanity, not only in those we serve but also in one another. We take pride in being part of a company that values and celebrates diversity—in experiences, ideas, and interests. We are empowered in an environment that embraces unity and inclusivity, fostering a sense of belonging and mutual respect.
We provide powerful tools to empower our employees to take charge of their career paths and reach their full potential. At ArsenalBio, we believe in investing in our employees' well-being—both professionally and personally—because our people are our most valuable asset. Our essential team members bring exceptional expertise in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software, and other fields to turn the possibilities of tomorrow into the realities of today.
We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.
We are an equal opportunity employer and deeply value diversity within our company. We do not discriminate based on race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability.
The estimated base salary for the preferred primary location of the San Francisco Bay area ranges from $110,200 - $135,000. Salary ranges for other locations may vary. Base pay offered may vary based on job related knowledge, experience, education, and location. In addition to these factors, we believe in the importance of pay equity and consider internal equity of our current employees as part of any final offer.
To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.
