Senior Research Associate II, Cell Isolation/Genome Engineering (23066-R-675-ATA)

South San Francisco /
Discovery /
/ On-site
ArsenalBio, a privately held, clinical-stage programmable cell therapy company engineering advanced CAR T therapies for solid tumors, is seeking a talented Senior Research Associate II to work on-site based in our South San Francisco office. 

ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic
diseases, initially cancer. With our programmable and computationally driven approach, our team is engineering living medicines to attack cancer’s inherent multi-faceted nature and overcome the challenges of addressing solid tumors with cell therapy.

Driven by a collective of diverse experts across immunology, synthetic biology, molecular biology, automation and computational biology, we are united in purpose to deliver radical breakthroughs for people with cancer, and prioritize the team’s outcomes over individual goals to achieve our company mission – together. 

We are seeking a talented and motivated Research or Senior Research Associate to support the ArsenalBio Discovery team. The individual will be responsible for participating in the development and execution of automated T cell isolation, genome engineering, and cell expansion processes and procedures that enable downstream workflows company-wide. This candidate will also be responsible for R&D efforts focused on optimizing and further improving Arsenal’s genome engineering workflows in primary human T cells using our proprietary non-viral engineering technology. The ideal candidate will have experience with mammalian cell culture, experience isolating primary human cells, experience performing flow cytometry, an understanding of CRISPR-Cas9 based cell engineering methods, and experience running laboratory automation including liquid handlers. This position will report to the Lead of the Arsenal T cell Armory (ATA) within the Pre-Clinical Pharmacology group.  The individual will also be a major part of expanding the core and research functionality of the ATA with cross-functional interactions with the Pre-Clinical Development, Immunology, Synthetic Biology, Process Development and Analytical Development teams, as well as across the organization to enable ArsenalBio’s success.

What You Will Do:

    • Work within the team to enable the core functionality of cell isolation and genome engineering workflows
    • Design and execute genome engineering studies to generate edited primary cells using both manual and automated methods.
    • Perform automated isolation of primary human T cells starting from enriched apheresis product
    • Act as a point person to identify the needs of the organization with respect to fresh primary human T cells and genome engineering services and ensure these needs are met.
    • Coordinate and integrate multiple different workflows into the cell isolation and genome engineering core activities.
    • Perform characterization of both isolated and gene modified T cell populations
    • Assist in the development and optimization of the cell processing platform
    • Perform troubleshooting and testing of experimental workflows
    • Keep detailed logs of studies to contribute to the dissemination of results
    • Support and maintain reagent inventory, instrument maintenance, SOP writing, and related administrative tasks

What Will You Bring:

    • Bachelors in cell, molecular, immunological, or genomic basis of human diseases and 4+ years experience.
    • Masters in cell, molecular, immunological, or genomic basis of human disease with 2+ years of research experience involving primary T cell culture and isolation.
    • Experience in cell processing ideally with systems such as the Miltenyi MultiMACS, Miltenyi MACS magnetic separation, Stemcell Technologies Easysep/Robosep, and equivalent platforms
    • Experience with targeted gene editing workflows including CRISPR-Cas9 technology
    • Experience developing multi-color flow cytometry panels and performing flow-based analysis on primary human cells
    • Experience with automation platforms, specifically Hamilton automated liquid handlers
    • Proficiency in basic molecular biology laboratory techniques, pipetting, PCR, and flow cytometry
    • Excellent written and verbal communication skills and proficiency in GSuite
    • Ability to quickly learn new skills and knowledge on the job, demonstrate productivity, and deliver high-quality results
What We Will Offer You: 
An opportunity to work with the best talent in the field of cell therapy, and be part of ONE TEAM to advance therapies to patients who need it most.

ArsenalBio has a generous and comprehensive benefits package that includes but is not limited to medical, dental, and vision as well as mental health resources, virtual and telehealth options, coaching, infertility treatment, parental leave and health savings accounts. We also offer flexible work schedules and flexible time off, which includes two extra “Arsenal Days of Rest” every quarter for employees to recharge. 

We have a robust mentorship program, and comprehensive development tools to help employees take control of their career paths and grow into their best selves. ArsenalBio believes in investing in the well-being of our employees - both at work and at home, as they are our greatest asset. They bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

ArsenalBio prioritizes the providing of a safe and healthy workplace that is consistent with COVID-19 public health guidance and legal requirements.  In order to protect our employees and visitors, we require all visitors (candidates) and employees to present proof of being fully vaccinated against COVID-19 when coming onsite.

We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

The estimated base salary offer for the preferred primary location of San Francisco Bay area ranges from $93,500 – $114,500. 
Salary ranges for other locations may vary from this range.   Base pay offered may vary depending on job related knowledge, experience, education, and location.  In addition to these factors, we believe in the importance of pay equity and consider internal equity of our current employees as part of any final offer.

To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.