Senior Associate Scientist, Viral Vector Cell Line Development
Boston, MA
Synthetic Biology /
Full-time /
On-site
Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.
We are seeking a Senior Associate Scientist, Viral Vector to join our Cell Line Development team in Boston, MA. The ideal candidate will have a proven track record performing lentiviral vector stable packaging or producer cell line development in an industry setting. They will be a key contributor to our team, participating in the creation of stable producer cell lines for lentiviral vector therapeutics and research projects to improve our cell line development workflows. They will also work closely with Asimov’s synthetic biology and process development teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering.
About the Role:
- Perform lentiviral vector stable producer cell line development processes including transfection, pool generation, single cell cloning, characterization, and cell banking using state-of-the-art equipment.
- Perform assays to assess quantity, potency and infectivity of lentiviral vector preparations.
- Support innovation through development of novel workflows and applications
- Support research projects to develop viral vector production methods to enhance product quality attributes such as empty/full ratio, potency and/or cell targeting.
- Work effectively as part of a cross-functional team in support of a Lentiviral CLD platform and in collaboration with Synthetic Biology and Process Development teams.
- Design experiments, analyze data, troubleshoot, and maintain detailed records.
- Represent LV CLD on project teams, making decisions for cell line development activities and effectively communicating results, progress and plans.
About You:
- B.S or M.S. in Biological Engineering, Virology, Cell Biology, Molecular Biology, or a related field.
- 5+ years of hands-on experience in biopharma with a minimum of 3 years focused on lentiviral vector producer cell line development in support of GLP or GMP production of cell or gene therapies.
- Extensive experience performing viral transductions, flow cytometry, and quantitative gene expression analyses (ddPCR or qPCR).
- Experience with downstream purification of lentiviral vectors, T-cell transduction assay, viral genome engineering, and/or host cell genome engineering related to virus production or producer cell line technologies is highly desired.
- Comfortable working with large, multidimensional datasets and applying statistical or computational methods to extract actionable biological or process insights.
- Strong written and verbal communication skills required.
We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.
