Scientist I/II, Medicinal Chemistry

Cambridge, MA /
Chemical Sciences /
Full-Time
Atavistik Bio is a new, privately-held biopharmaceutical company focused on the discovery and development of novel therapies for metabolic diseases and cancer. Our high-throughput platform for the unbiased identification of metabolite-protein interactions will enable the discovery of first-in-class drugs inspired and empowered by nature’s own mechanisms of allosteric control. Our unique approach marries this validated platform with structure-aided drug design capabilities and cutting-edge insights into the regulation of metabolic systems to apply to genetically validated targets.

Position Summary:

We are looking for an enthusiastic and self-driven medicinal chemist to join Atavistik’s Discovery group. This individual will contribute to shape the growing medicinal chemistry organization, drive innovation, and ensure project goals are delivered on time. The individual will play a central role in collaborating with both internal and CRO researchers in enabling new projects for drug discovery at Atavistik. Successful candidates will be able to thrive in a fast-paced environment and be passionate about science.

Key Responsibilities

    • Design and implement medicinal chemistry and drug discovery strategies for novel small molecule projects from Hit finding to IND-enabling studies. Prepare, document, and troubleshoot synthetic strategies to discover new small molecule compounds. Able to work independently.
    • Provide scientific direction to drive progression of drug discovery projects from screening to development candidate. Contribute to multi-disciplinary teams, utilizing cross-functional data to drive drug discovery strategies in a matrix organization environment.
    • Collaborate with cross-functional partners in biochemistry, biology, molecular pharmacology, etc. to drive programs to key go/no go decisions.
    • Present scientific results internally in a concise and effective manner, including scientific challenges, and strategy development to address any issues
    • Contribute to fostering an inclusive work environment 

Required Qualifications

    • Ph.D. or MS/BS in organic chemistry or a related scientific discipline, with 3-5 years (Ph.D.) or 7-10 Years (MS/BS) drug discovery in the biotech industry. Experience managing a CRO is desirable.
    • Robust knowledge of modern synthetic and purification methods, ability to independently design and synthesize relevant compounds to address key issues within medicinal chemistry, including structure-based drug discovery (SBDD).
    • Fluency with 3D visualization programs, compound management, eLN, registration, and database software.
    • Thrive in a fast-paced matrix organization, learning agility, and collaborative approach with cross-functional groups (biophysics, structural biology, modeling, and pharmacology)
    • Excellent oral and written communication skills, ability to present results in a concise and clear way
    • Strong interpersonal skills, ability to influence at all levels
    • Highly organized, self-motivated, and desire to succeed in a fast-paced organization
For immediate consideration please share your CV complete with a full list of publications.

Atavistik Bio offers competitive compensation, including stock options, and a comprehensive benefits package that includes paid time off, medical, dental, vision, life insurance, and a flexible spending account for dependent care.


Atavistik Bio is proud to be an inclusive employer and all individuals seeking employment with us are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.