Biochemistry & Biophysics Scientist

Cambridge, MA /
Platform /
Atavistik Bio is a new, privately-held biopharmaceutical company focused on the discovery and development of novel therapies for metabolic diseases and cancer. Our high-throughput platform for the unbiased identification of metabolite-protein interactions will enable the discovery of first-in-class drugs inspired and empowered by nature’s own mechanisms of allosteric control. Our unique approach marries this validated platform with structure-aided drug design capabilities and cutting-edge insights into the regulation of metabolic systems to apply to genetically validated targets.

Position Summary:

We are looking for a multitalented and self-driven individual with a strong background in biochemical and biophysical assay development. As a startup company, this is a great opportunity to collaboratively build and contribute to the drugging strategy. The ideal candidate will have a strong background in assay development, an in-depth understanding of biochemistry and biophysics, and experience with small molecule drug discovery programs. The individual will play a central role in close coordination with internal scientists and collaboratively enable new projects for drug discovery.

Key Responsibilities:

    • Independently design, develop biochemical and biophysical assays for target enablement and hit finding
    • Characterize proteins, troubleshoot experiments, optimize assays suitable for SAR development
    • Conduct enzyme mechanism of action studies to guide screening and drug discovery approaches
    • Organize, manage, and analyze experimental data
    • Collaborate with diverse project teams internally to champion lead discovery and progression of small molecules
    • Analyze and present results at cross-functional teams

Required Qualifications:

    • MS with 8-10 years or BS with 10-12 years or Ph.D. with 0-4 years of experience in small molecule drug discovery industry
    • Extensive experience in biochemical and binding assay development with a variety of readout formats (Fluorescence, FRET, LC-MS, FP, etc.)
    • Hands-on knowledge of biophysical methods such as SPR, DSF, SEC-MALS, ITC, etc. is required
    • Experience in assay optimization, steady state kinetics, mechanism of action studies, compound profiling, and screening
    • Experience in protein purification using AKTA systems
    • Excellent communication and collaborative skills to work on the project team with biologists, chemists, and metabolism scientists
    • Highly organized, self-motivated with the desire to succeed 
For immediate consideration please share your CV complete with a full list of publications.


Atavistik Bio offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, and a flexible spending account for either health care and/or dependent care.

Atavistik Bio is proud to be an inclusive employer and all individuals seeking employment with us are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.