Principal Scientist, Bioconjugation

Redwood City, CA /
Chemistry /
/ On-site
Who We Are
Bolt Biotherapeutics, based in the San Francisco Bay Area, is a clinical-stage biotechnology company developing Boltbody™ Immune-stimulating Antibody Conjugates (ISACs), a new class of immuno-oncology therapeutics. This is a unique opportunity to join and build, with like-minded colleagues, a company that will transform the lives of individuals with cancers.

Key Responsibilities
• Prepare conjugated proteins on various scales (mg to g) using classical and modern bioconjugation techniques
• Purify and characterize complex bioconjugate therapeutics and when appropriate, develop new synthetic and analytical methods and protocols
• Make immediate contribution at the bench by independently analyzing results and troubleshooting experiments
• Be a key intellectual contributor assessing and evaluating new conjugation techniques for Bolt’s technology platform
• Collaborate with chemists, biologists, and pharmacologists to interpret in vitro and in vivo assay results and propose means to advance programs and Bolt’s technology platform
• Ability to critically evaluate, summarize, and interpret data, in addition to effectively communicating scientific concepts, findings, and interpretations at group, project team and departmental research meetings
• Contribute to the writing of technical documents, patents, scientific manuscripts, etc.
• Understand published scientific and patent literature outside of their immediate area of expertise and apply this understanding to drive innovation

• Ph.D. in Chemistry, Chemical Biology, Biochemistry or closely related field with 8+ years of direct experience in bioconjugation; or MS/MA or BS/BA with commensurate experience
• Extensive experience with bioconjugate therapies or targeted drug delivery modalities
• Hands on experience optimizing conjugation conditions for DAR, recovery, and stability
• Hands on experience purifying conjugates at various scales (mg to g)
• Extensive analytical experience characterizing bioconjugates
• Strong understanding of modern bioconjugation techniques and organic chemistry
• Experience with scale-up manufacturing supporting early development research a plus
• Project Team Leadership experience a plus
• Requires working in a laboratory environment with hazardous chemicals. Protective clothing, gloves, and safety glasses are required while working in the lab
• Ability to lift containers or instruments (up to 25 pounds) and work standing at a fume hood or lab bench for extended periods
We are an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.
Bolt Biotherapeutics requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Bolt will consider requests for Reasonable Accommodations.
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.