Scientist/ Sr. Scientist, CAR T Biology

Foster City /
Immunology /
Full-Time
Cartography Biosciences is a therapeutics organization creating the first atlas to identify targets that are specific enough to only engage cancerous cells, broad enough to work across cancer cells and patients, and safe enough to sidestep toxic side effects. Founded by Kevin Parker, Howard Chang, and Ansu Satpathy, Cartography is bridging immunology and computation to understand the critical differences between normal and cancerous cells, ultimately solving the challenge of finding the safest, most selective targets for a variety of immunotherapeutic approaches. 

Our Immunology team is seeking an experienced and driven immunologist or CAR T biologist to help build and advance our cell therapy platform capabilities. Reporting to our VP of Immunology, you will be responsible for working with the cell modeling, platform and in vitro pharmacology teams to generate and evaluate CAR T cells against novel Cartography targets of interest, as well as design and/or implement in vitro assays and/or screens that provide a framework for evaluating CAR T products throughout various states of function/dysfunction. 

Our ideal candidate will have extensive knowledge of T cell biology including activation, signaling, differentiation and immune-regulation pathways, coupled with a track record of success in cell therapy or immuno-oncology drug discovery. This position is in a highly collaborative, innovative and rapidly evolving environment and interfaces with multiple teams and functions across the organization.

What You'll Do:

    • Apply your T cell biology, differentiation and immune regulation expertise to develop strategies to design assays that permit interrogation of CAR T cells throughout various cellular states
    • Devise screens to enable HT evaluation and selection of lead binders
    • Leverage existing internal capabilities as well as be willing and eager to apply novel ideas from the literature and other disciplines to innovate in a rapidly evolving field
    • Help develop and mentor junior scientists on our team

About You:

    • Ph.D. in Immunology, Immuno-oncology or Molecular/cellular Biology with at least 3 years of successful postdoctoral experience as demonstrated by a strong publication record, plus 3+ years of industry experience, or a B.S./ M.S. with 13+ years of relevant industry experience in immunology
    • Broad working knowledge of platforms and technologies used to evaluate T cell function and/or heterogeneity including but not limited to in vitro stimulation assays, high-dimensional FACS or spectral cytometry for phenotypic or functional analysis, transcriptional or epigenetic assessment, population labeling/tracking or fate-mapping, and/or other single-cell analytics
    • Self-motivated and functional as an individual contributor, as well as in a highly collaborative team-based environment
    • Excellent written and verbal communication, and strong organizational skills to facilitate managing multiple projects at once in a matrix environment
Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities, and activities may change at any time with or without notice.

Cartography Biosciences is an equal opportunity employer and is committed to an inclusive, open working environment and a diverse workplace. People from diverse racial, ethnic and cultural backgrounds, women, LGBTQ+ individuals, and persons with disabilities are highly encouraged to apply. Cartography is also committed to providing employees with opportunities for growth and skill acquisition. As a Cartographer, you will be exposed to cutting-edge molecular biology and computational methods development and have opportunities to learn, grow, and diversify your skillset.