AIRR Sequencing Scientist

New York, NY
Imprint (Stealth) – Imprint (Stealth) /
Full Time /
This is an exciting opportunity to join a fast-paced, growing Focused Research Organization (FRO) startup (currently in stealth). We are seeking a highly motivated scientist to conduct NGS-based experimental research and contribute to novel assay development in a dynamic, interdisciplinary environment. The successful candidate will develop high-throughput workflows and generate datasets from adaptive immune cells, including bulk RNA-seq, single cell RNA-seq, long-read sequencing, BCR sequencing, and barcoded antigen labeling. This individual will work closely with other top-tier experimental and computational scientists to create groundbreaking new insights into adaptive immunity.


    • Aid in planning and executing NGS-based sequencing experiments to profile adaptive immune responses in coordination with interdisciplinary team of computational, immunology, and molecular biology scientists.
    • Design and prepare DNA and RNA libraries from immune cells.
    • Performing in-house QC checks and maintain high standards for sequencing quality, in line with industry best practices.
    • Help establish and optimize sequencing workflow SOPs for NGS assays.
    • Aid in maintaining sequencer uptime, and manage reagent inventory.
    • Contribute to the development of novel NGS and multiomics assays and research, inclusive of experimental design.
    • Assist in procurement and maintenance of supplies, chemicals, and biological inventories. 
    • Communicate study findings efficiently and present data at various internal and external meetings as projects progress.
    • Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

Key Qualifications

    • BS, MS, or PhD in biomedical engineering, genetics, immunology or related field that relies on next-generation sequencing applications.
    • High proficiency with nucleic acid preparation from eukaryotic sources, preferably adaptive immune cells.
    • Experience with library design and preparation for next-generation sequencing.
    • Familiarity with state-of-art methodology for bulk RNA-seq, single cell RNA-seq, and **AIRR / BCR / TCR profiling.**
    • Experience processing diverse single-cell raw data using Cell Ranger and alternative / open-source pipelines
    • Comfort running multiple projects simultaneously with different priorities and timelines.
    • Strong organizational, time management, and communication skills.

Advanced Qualifications

    • Prior experience in adaptive immunity research. (strongly preferred)
    • Familiarity with diverse next-generation sequencing technologies such as Pacific Biosciences, Oxford Nanopore, and/or Ion Torrent. (strongly preferred)
    • Experience with single-cell multiomics techniques (eg, CITE-seq, LIBRA-seq), long-reads, and / or proteomic antibody sequencing (Ab-seq). (strongly preferred)
    • Familiarity with diverse microfluidics, microwell, and microfluidics-free platforms.
    • Experience with liquid handling automation for sequencing library preparation.
    • Proficiency in custom protocol development.
    • Experience with novel assay development.
    • Competence in R and/or Python with familiarity with scVerse tools, scVi tools, Scanpy or Seurat, as well as antigen-specific analysis using scRepertoire, Immcantation, or related tools.
    • Experience generating immunological insights from single cell sequencing data.

We Offer

    • Competitive compensation $90,000 - $120,000 a year (salary based on years experience)
    • Excellent medical, dental, and vision insurance
    • Generous time off + paid holidays
    • A supportive environment to learn and develop new skills
    • An opportunity to participate in high-impact, fast-paced, cutting-edge, collaborative team science; contribute to curing disease; and work with leading experts from different fields
    • Exciting location in the Soho area of Manhattan
We aim to help fill a structural gap in today's R&D system. We enable fundamental research that requires unusual levels of scale and coordination yet is not rapidly monetizable by industry. We’re bringing together top talent from academia, industry, and startups to build a new model for innovative R&D. As an incubator within the Schmidt Futures Network, we identify high-impact scientific or technical research and development opportunities, ultimately defining and launching these projects as Focused Research Organizations.
We are an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.