Director, Translational Research

Remote - Work From Home anywhere in US /
Research & Development – Translational Research /
Full Time
/ Remote
Day One Biopharmaceuticals is an emerging, mission-driven, drug development company intentionally designed to identify, clinical evaluate, and successfully commercialize novel treatments for pediatric oncology patients, and ultimately to expand those benefits to patients of all ages. For more information, please visit our website at
Day One Biopharmaceuticals is seeking an exceptional individual and scientist to support translational research activities across our portfolio of targeted therapeutics for children and adults with cancer.  The successful candidate will work closely with cross-functional teams to drive translational research across pipeline programs. This individual will be a key member of the Translational Research group within our Research and Development organization and help us achieve the forward and reverse translational research that is critical to successful pediatric and adult oncology drug development. This role will report to our Vice President, Translational Research.

Ideally located in San Francisco Bay Area; otherwise willing to travel to San Francisco for work/meetings; occasional travel will be required for offsite meetings.

·       Contribute to translational research in oncology, including designing and executing strategies for patient stratification and biomarker development across all pipeline programs
·       Work cross-functionally and interact closely with both clinical and research groups
·       Drive in vitro studies from design to completion to support hypothesis-driven patient stratification strategies, identify and validate novel biomarkers, and guide potential combination strategies in both pediatric and adult oncology programs
·       Drive translational biomarker activities in research and successful implementation of key biomarkers into clinical trials
·       Manage translational scientist team
·       Select, establish, and manage relationships with external CROs and academic collaborators for translational research
·       Actively participate in internal and external scientific meetings through presentations and critically evaluate both internal results and emerging scientific literature
·       PhD in cell biology, cancer biology, pharmacology, or a related scientific field
·       10+ years of drug development in biopharmaceutical industry
·       Demonstrated solid scientific background and understanding of small molecule oncology drug development, patient indication and combination strategies
·       Experience in translational research and biomarker assay development
·       Strong background or experience in range of platform technologies including NGS, IHC, PCR, FISH, flow cytometry and their clinical application
·       Experience and demonstrated skills in translating mechanistic biology and preclinical research into clinical biomarker, patient stratification, and combination strategies
·       Experience managing CROs and consultants; experience working in partnership with academic collaborators
·       Ability to analyze, interpret, and clearly communicate data and its impact on program strategy
·       Excellent oral and written communication and presentation skills, and ability to work as effective team member in highly collaborative, fast-paced start-up biotech work environment
·       Strong analytical skills and problem solving capabilities
·       Excellent organization skills and ability to manage projects to meet key deliverables
·       Ability to work independently and interact effectively in cross-functional collaborative teams
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification.
The salary range for this position is $215,000 – 230,000. Day One Bio considers a range of factors when determining base compensation. These considerations mean actual compensation will vary.
Please visit to see our competitive benefits.
Day One is committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law.
Employment is conditioned upon full vaccination from the COVID-19 virus, including submission of documented proof thereof, as of the start date.  Day One Biopharmaceuticals will comply with applicable law regarding the reasonable accommodation of individuals who are not vaccinated because of a disability and/or sincerely held religious belief.
Recruitment & Staffing Agencies: Day One Biopharmaceuticals does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Day One Biopharmaceuticals or its employees is strictly prohibited unless contacted directly by Day One Biopharmaceutical’s internal HR team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Day One Biopharmaceuticals, and Day One Biopharmaceuticals will not owe any referral or other fees with respect thereto.