Bioinformatics Scientist/Sr. Bioinformatics Scientist

Baltimore, MD /
Genomic Science – Genomic Science /
Full-Time
/ On-site
About Us

Our mission is to cure cancer through high performance, accessible early cancer detection.  That means saving lives. 

Delfi Diagnostics is a Johns Hopkins spinoff focused on the non-invasive detection of cancer at earlier stages, when it is most curable. DELFI uses artificial intelligence and whole genome sequencing to detect unique patterns of DNA fragmentation in the blood of patients with cancer. These analyses are performed through simultaneous examination of millions of DNA sequences using machine learning to identify tumor-specific abnormalities.

In our passionate pursuit to radically improve health outcomes, we serve humanity when we:

Lead with Science, Anchor in Pragmatism: We pioneer life-changing science by ensuring quality, transparency, and rigor at all times. We explore thoughtfully, experiment smartly, and deliver impact with conviction.

Build With & For All: We embrace diverse backgrounds to innovate and achieve together. We are not just building a product - we aim to disrupt the path of cancer for all - no matter geography or socioeconomic class 

Put We over I: We are a home for high-performing people. Through teamwork, we build collective intelligence. Each of us wins when those we serve and those who serve with us--win. We show up with empathy, humility, and integrity at every step of the journey.

In this position, you will have a key role in the Genomic Sciences team and work cross functionally in a research setting to apply your knowledge of biology and bioinformatics to enhance the DELFI cfDNA fragmentation assay.  You will collaborate on study design and analyze and interpret genomic data to improve performance of the Delfi assay and develop new applications for this novel approach in oncology.

What you'll do

    • You will contribute to the conception and design of genomic studies and perform end-to-end analyses that include data gathering, processing, analysis, interpretation and presentation of results
    • You will develop new bioinformatics processes and use computational tools to extract actionable information from sequencing data
    • You will analyze complex genomic datasets to generate biological insights in the context of cancer detection and progression
    • You will identify and evaluate new opportunities for applications of the Delfi cfDNA fragmentation platform
    • You will review and analyze relevant literature in cancer biology and molecular diagnostics and effectively communicate results of published data to the broader research team
    • You will work closely with team members from Data Science and Translational Science to generate and analyze data to enable the company’s goals.

What you'll have accomplished 12 months from now

    • You will have identified novel features and applications of the DELFI assay and assessed their impact on performance in collaboration with other members of the Genomic Science, Translational research, Bioinformatics and Data Science teams
    • You will have contributed to the design and execution of fundamental studies to support company's products on their concept phase
    • You will have used your experience in Cancer Biology and Bioinformatics to drive the development of novel analysis approaches
    • You will have acquired new expertise related to chromatin biology and bioinformatic approaches benefiting from mutual knowledge exchange with your colleagues
    • You will be a respected member of the research team having collaboratively contributed to the design, analysis and interpretation of wet and dry lab studies

What you'll bring to DELFI


    • Required
    • PhD in Bioinformatics, Cancer Biology, Genetics, Genomics or similar biologics with experience in Bioinformatics
    • Expertise in genomics (preferably cancer genomics) and analyzing large datasets
    • Proficiency in Python
    • Ability to perform exploratory data analyses and visualization using R
    • Ability to effectively communicate results to a range of audiences
    • Preferred
    • Expertise in circulating tumor DNA (ctDNA)
    • Familiarity with chromatin biology and epigenetics
    • Familiarity with public genomic databases such as TCGA and gnomAD
    • Experience with AWS
Delfi’s Covid-19 Vaccination Mandate: Delfi Diagnostics requires that all employees be fully vaccinated for Covid-19.  Proof of vaccination or sincerely held religious belief and/or medical exemption is required upon hire. Delfi Diagnostics will engage in an interactive dialogue process with employees who have documented medical conditions and/or sincerely held religious beliefs that would prevent them from getting vaccinated, in accordance with all applicable laws.

An equal opportunity employer

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.