Senior Scientist, Antibody Generation

Massachusetts
Protein
Full-time

About Dragonfly
Founded in 2015 by Dr. Tyler Jacks, head of the Koch Institute at MIT, Dr. David Raulet, one of the world's leading experts in Natural Killer (NK) cell biology, and Bill Haney, a longtime tech entrepreneur and investor, Dragonfly Therapeutics develops novel first-in-class therapeutics targeted at Natural Killer cells and other cells of the innate immune system. Our therapies are designed to counterbalance immune suppressive factors present in the tumor microenvironment and mobilize anti-cancer immune responses, and are expected to be potent as single agents as well as in treatment combinations with existing cancer immunotherapies – such as T cell treatments.  Dragonfly’s Scientific Advisory Board and founders are major figures in cancer biology and immunology, and launched Dragonfly to harness the power of the immune system to provide breakthrough cancer treatments for patients.

Senior Scientist, Antibody Generation
Dragonfly Therapeutics seeks a highly motivated and talented protein scientist with structural biology background to join the Biologics team and make significant contributions to development of therapies using a novel immune-oncology platform. The successful candidate will be responsible for protein engineering, modeling, purification and in-depth characterization of different bispecific and trispecific antibody drug candidates.
 
Responsibilities:
·         Play a key role in designing and developing formats for bispecific and trispecific antibody generation
·         Facilitate antibody discovery and characterization projects through internal resources and CROs
·         Design and perform assays to assess developability profile of different drug candidates
·         Work closely and interface collaboratively with other groups in a multidisciplinary company
·         Train junior personnel
Basic Qualifications:
·         Ph.D. in Structural Biology, Biochemistry or related discipline with 3+ years of   industry experience with emphasis on protein structure, molecular modeling, purification, characterization and properties optimization of antibody based therapeutics.
·         Demonstrated expertise and in-depth understanding of antibody discovery, characterization, sequence optimization and generation of multi-specifics biologics
·         Hands on experience with molecular modeling, detailed knowledge of sequence liabilities and direct experience with optimization of mono-specific and bispecific molecules
·         Working knowledge of BioIuminate, MOA or similar modeling software
·         Extensive experience in purification of mono- and bispecific antibodies, receptors and ligands using affinity, IEX, SEC, HIC, CHT, RP chromatography.
·         Hands-on experience with SPR (Biacore 8K, T200), DSF and DSC
·         Experience with analytical characterization techniques such as SEC, IEX, HIC, RP-HPLC, SEC-MALS
·         Deep understanding of developability profiling for biologics
·         Strong publications and/or proven record of optimizing large molecules and multi-specific formats
·         Knowledge of immunology/oncology  is highly desirable
 
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We are excited to review your application~ please give us 10 business days to respond!

Best,
Dragonfly hiring team