Science Team Lead – Cellular Reprogramming
Portland, Oregon
Meiotic induction /
Full time /
On-site
About us
e184 is a biotechnology research company advancing in vitro gametogenesis to transform reproductive medicine. We're developing integrated platforms that combine cellular reprogramming, machine learning-guided optimization, multi-omics analysis, and automated experimental workflows to enable gamete development for individuals facing reproductive challenges. We're assembling interdisciplinary teams across cell and molecular engineering, synthetic biology, epigenetic editing, bioinformatics and computational biology to tackle one of biology's most impactful problems - returning the fundamental right to procreate.
Role overview
We are seeking a Science Team Lead to drive our innovative research program developing novel approaches to cellular fate conversion through transcription factor-mediated reprogramming. This is a leadership position reporting directly to the Chief Scientific Officer (CSO). The successful candidate will guide scientific planning, supervise project execution, contribute to team building, and shape the long-term R&D roadmap. This is a hands-on role: in addition to team leadership and project management, the candidate will be directly involved in designing and conducting experiments at the bench (wet lab), especially in early stages of the program.
What you will do
- Lead a focused research team of 4-6 scientists and report directly to the CSO
- Design and personally conduct hands-on research in cellular reprogramming, high-throughput screening, and cell cycle manipulation
- Develop and optimize reporter cell line platforms with integrated fluorescent markers for cellular state transitions
- Establish large-scale screening protocols using CRISPRa and transposon-based transcription factor libraries
- Design and execute pooled genetic screens to identify factor combinations driving targeted cellular conversions
- Supervise validation studies for cellular reprogramming candidates using cytological and molecular approachesImplement high-content imaging systems for phenotype detection and validation
- Work with executive leadership to define research approaches and priorities aligned with company objectives
- Drive scientific output, IP development, and milestone achievement within established timelines
Required qualifications
- PhD in Cell Biology, Molecular Biology, or related field
- Minimum 5 years postdoctoral or industry experience in directed cell fate conversion high-throughput genetic screening
- Demonstrated expertise in reporter cell line development and validation
- Technical proficiency in pooled genetic screening methodologies (CRISPRa, library construction, barcode analysis)
- Experience with flow cytometry, FACS, and high-content imaging systems
- Strong background in cell cycle regulation, chromosome imaging, and cytological analysis
- Proven ability to design and execute complex multi-parameter screening experiments
- Experience leading research teams while maintaining significant hands-on involvement
Preferred qualifications
- Targeted DNA methylation editing (CRISPR-based fusion protein systems) gRNA design and CRISPR construct optimization
- Understanding of genomic imprinting mechanisms
- Long-read methylation analysis (e.g., Oxford Nanopore, PacBio)
- Haplotype phasing and whole-genome methylation profiling
- RNA-seq, ATAC-seq, chromatin dynamics and accessibility analysis
What we offer
- On-site work on the US Pacific West Coast
- Competitive compensation and benefits package (discussed during an interview process)
- A high-impact leadership role in a mission-driven biotech environment
- Health insurance provided; relocation support negotiable
- Opportunity to shape early-stage scientific vision and company growth
- Collaborative and intellectually stimulating workplace
- Supportive (yet very driven) work environment where your voice and ideas truly matter and quickly translate into decisions and actions.
Disclaimer
The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of e184.
