Science Team Lead - Epigenetic Reprogramming
Portland, Oregon
Epigenetic editing /
Full time /
On-site
About us
e184 is a biotechnology research company advancing in vitro gametogenesis to transform reproductive medicine. We're developing integrated platforms that combine cellular reprogramming, machine learning-guided optimization, multi-omics analysis, and automated experimental workflows to enable gamete development for individuals facing reproductive challenges. We're assembling interdisciplinary teams across cell and molecular engineering, synthetic biology, epigenetic editing, bioinformatics and computational biology to tackle one of biology's most impactful problems - returning the fundamental right to procreate.
Role overview
We are seeking a Science Team Lead to drive our innovative research program developing advanced epigenetic editing technologies for therapeutic applications. This is a leadership position reporting directly to the Chief Scientific Officer (CSO). The successful candidate will guide scientific planning, supervise project execution, contribute to team building, and shape the long-term R&D roadmap.This is a hands-on role: in addition to team leadership and project management, the candidate will be directly involved in designing and conducting experiments, especially in early stages of the program.
What you will do
- Lead a focused research team of 4-6 scientists and report directly to the CSODesign and personally conduct experiments in DNA methylation editor optimization and validation
- Develop guide RNA libraries targeting chromatin regulatory regions
- Establish protocols for targeted methylation editing with persistence validation through cell divisions
- Create delivery strategies for enhanced efficiency in challenging cell types
- Execute single and multiplex editing approaches with maintained specificity across targets
- Drive progression from cell culture proof-of-concept to functional validation in mammalian models
- Define research approaches and priorities aligned with company objectives
- Drive scientific output, IP development, and milestone achievement within established timelines
Required qualifications
- PhD in Molecular Biology, Epigenetics, Developmental Biology, or related field
- Minimum 5 years postdoctoral or industry experience in epigenetic editing, chromatin modification, or CRISPR-based technologies
- Proven expertise developing DNA methylation editors including fusion protein design and optimization
- Hands-on experience with guide RNA design and validation for chromatin targets
- Advanced skills in DNA methylation and chromatin modification analysis
- Knowledge of chromatin biology, gene regulation, and epigenetic inheritance mechanisms
- Experience leading research teams while maintaining significant hands-on involvement
Preferred qualifications
- Experience with allele-specific epigenetic editing approaches
- Track record of integrating innovative experimental and computational approaches in epigenetic editing with publications in high-impact journals and experience in IP development
- Familiarity with mammalian reproduction models and developmental biology applications
What we offer
- On-site work in the US Pacific Northwest in state-of-the-art facility
- Competitive compensation, equity participation, and comprehensive benefits
- Collaborative and supportive culture with mission-driven colleagues focused on breakthrough discoveries
- Opportunity to build pioneering technology platform with high therapeutic potential
Disclaimer
The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of e184.
