Enveda - Principal Scientist

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(Transcription) - Candidate experience will always be top priority for Enveda. We would like to offer you the opportunity to have your virtual interviews transcribed. This will allow your interviewer to spend less time notetaking and more time being present and engaged with you. In addition, transcriptions may help to expedite feedback so you will know what is happening with your candidacy sooner. You can opt out at any time which will not affect your candidacy. Opting in enables you to request a copy of the transcription.✱

How many years of hands-on experience do you have specifically in medicinal chemistry or preclinical drug discovery in CRO/IDD environments? Describe the therapeutic areas and project stages you've worked on.✱
Walk us through your approach to rational drug design. Starting with a novel biological target, describe the steps you would use to identify/choose initial hit compounds and optimize them into lead candidates.✱
When analyzing freedom-to-operate for a new chemical series, which database searches are most critical to perform first?✱
- SciFinder and Reaxys only
- Patent databases (USPTO, EPO, WIPO) and chemical literature
- Internal company databases only
- PubMed and Google Scholar
Which physicochemical property changes would you prioritize to improve the oral bioavailability of a compound with MW=650, LogP=5.2, and TPSA=140?✱
- Increase molecular weight and reduce TPSA
- Reduce molecular weight and LogP, maintain TPSA
- Reduce molecular weight and TPSA, optimize LogP
- Only focus on reducing LogP
You have a team of 8 chemists working on parallel SAR exploration, but productivity has decreased and timelines are slipping. Describe your specific management approach to diagnose the issues and restore high productivity while maintaining team morale.✱

Principal Scientist