Director, Therapeutic Payload

South San Francisco, CA /
Therapeutic Payload /
Full Time
GenEdit is a rapidly-growing, early-stage company that is developing a proprietary and novel delivery platform with the potential to transform genetic medicine. Our interdisciplinary team works together across chemistry, payload, formulation, screening, and preclinical groups to develop the next generation of gene therapies. GenEdit fosters an exciting and dynamic environment where we value impactful data and creative solutions to accelerate our progression from a platform technology to a pipeline of therapeutic candidates. We are seeking talented and motivated individuals to join our team and are expanding across all functions within the organization. Join us in South San Francisco, CA, to be at the forefront of the future of gene therapy.

The Director of Therapeutic Payload is a key leadership role in the Research organization, responsible for executing the payload strategy within the research organization. The successful candidate will be able to support the growth and expansion of the payload team.

This is a critical leadership position, focused on executing the strategy, delivering the science as well as delivering the optimal payload that adequately responds to the program needs and specificities. He/she will work closely with all the functions within the company (chemistry, formulation, cell biology, and preclinical) as well as with our external partners and CROs. The Director of Therapeutic Payload will directly report to the Chief Scientific Officer (CSO) and will be responsible for managing a small team to plan, execute and deliver the short and long-term Research strategy. Through his/her deep scientific understanding of gene modulation (gene silencing, editing, and replacement), he/she will be able to provide the guidance needed to design and evaluate innovative therapeutic cargos with the goal to initially address serious diseases. This person will be a recognized expert in developing therapeutic nucleic acid (ASO, siRNA, etc.) and/or CRISPR-based therapeutics. This person will have experience working within a matrixed organization responsible for all aspects of the program from cargo design to in vitro verification of therapeutic activity. The Director of Therapeutic Payload will also establish a strong network of external CRO partners to support internal work as needed.

The Director of Therapeutic Payload will be a contributing member of the Research Management team to plan and execute on company objectives and the research strategy for all programs. This person must have a broad and fundamental understanding of gene therapy concepts and the underlying science and technologies behind the development of genetic medicines. This person must be a critical problem solver, creative and comfortable in a dynamic, start-up environment to find solutions to scientific, technical, and resource allocation issues to move programs forward. The ideal candidate will be a team player with excellent communications skills and work collaboratively across all functions within the company.


    • Vision: The Director Payload will support the development of the vision for the Payload Team and will be responsible for executing the relevant agreed and prioritized strategies.
    • Running of the payload team: Management and establishment of the payload team to support all research activities on the design and innovation on the payload from gene editing to gene replacement, including protein and drug from small scale testing up to GLP evaluation balancing the execution of payload production between internal efforts to external vendors including collaborative work with external parties (CRO, universities). Prepare and track annual department budget and allocate resources appropriately to effectively further the company pipeline. Present relevant progress to Senior Management Team and/or Board of Directors
    • Supervision: The Director payload is responsible for the hiring, motivation, development, and supervision of highly talented Scientists & Research Associates responsible for all activities in the payload team. Provide strong leadership, clear direction, development opportunities, and open communication to direct and indirect reports as well as mentor junior level staff and acting as a resource for scientific expertise.
    • Innovation: The Director of payload will identify new IP and work closely with the patent attorney to fill internal patents and work closely with the Senior Director of Corporate Strategy and the CBO to evaluate relevant innovative technologies as required.
    • Collaboration: The Director payload is responsible for establishing a strong collaboration across the whole organization and in particular with the VP Chemistry and VP of Therapeutic Product & Process Development to deliver novel vectors as well as with the Head of cell biology to evaluate the different payloads in a relevant cell system.
    • Communication: Serve as Genedit speaker and ambassador at conferences, advisory boards, regulatory interaction, etc, as appropriate.

Education and Qualifications:

    • Ph.D, M.D., or equivalent in Bioengineering, Biochemistry, Molecular Biology, Cell Biology, Neurobiology, or related life science field
    • At least 10 years of scientific/pharma research experience with at least 5 years of experience of management/leadership experience overseeing project/research team members.
    • Experience networking within the life science ecosystem with the proven ability to establish a collaborative working relationships with in-house team members, academic laboratories, and industry thought leaders.
    • Intellectually agile and able to thrive in a fast-paced, innovative environment
    • Work authorization in the US is required

Skills and abilities:

    • Strong direct experience with design and evaluation of ASO, siRNA, miRNA, and/or CRISPR-based therapeutics
    • Experience with chemical and structural nucleotide modifications of siRNA and other RNA therapeutics including PS, 2’-OMe, 2’-Fluoro, and LNA
    • Proven track record for team management and leading an RNA therapeutic program in an industry setting
    • Expertise in NGS analytical methods to model CRISPR on-target and off-target activity is a plus
    • Experience with qRT-PCR, RNAScope, and related assays is a plus
    • Excellent oral and written communication skills
    • Ability to develop and execute the payload vision & strategy
    • Creative and pro-active approach to problem-solving
    • High-level analytical capability

Personal attributes:

    • Personable, sociable, and eager  to help define Genedit’s future and culture
    • Willingness to both lead and work as part of a team and to be open-minded, flexible, and cooperative in a dynamic and fast-growing company
    • Highly professional, motivated, energetic, and “can-do”, problem-solving attitude
    • Ability to represent Genedit as the main contact point in working with external collaborators and/or potential partners
    • Discipline and regard for quality, safety, confidentiality, and security at all times
At GenEdit we are always looking to hire the absolute best talent and recognize that diversity in our experiences and backgrounds is what makes us stronger. We hire candidates of any race, color, ancestry, religion, sex, national origin, sexual orientation, gender identity, age, marital or family status, disability, veteran status, and any other status. These differences are what enable us to work towards the future we envision for ourselves, and the world.