Director/Senior Director of DMPK

San Diego, CA
Chemistry /
Full-time /
Genesis Therapeutics is pioneering artificial intelligence guided rational drug design to address severe unmet medical needs for patients. Our lab in San Diego is looking for an experienced, motivated, and versatile Drug Metabolism and Pharmacokinetics (DMPK) Director or Senior Director to lead of DMPK team and to help advance our compounds through preclinical and clinical development. The successful candidate will provide leadership and guidance in the design, analysis and reporting of in vitro and in vivo DMPK/ADMET studies to support our small molecule drug discovery and early development pipeline. The candidate will also participate in data integration best practices for AI ADME predictive model. 
This is a full-time position in a fast-paced biotech environment with a collegial group of high performing colleagues working towards well-defined goals. Full medical and dental benefits, flexible work hours/vacation included in this opportunity to learn all aspects of biotech start-up.

Learn more about us here:

And our recent collaboration with Eli Lilly here:

What You Will Do:

    • Represent DMPK as an integral member of project/core teams, providing scientific and strategic leadership for all stages of drug discovery and early development.
    • Lead the DMPK team (2-3 scientists) and built internal DMPK assay capabilities to support internal programs.
    • Effectively manage CROs and DMPK team to design and execute in vitro and in vivo studies aimed at characterizing the DMPK/ADME properties of small molecule drug candidates.
    • Communicate DMPK data and provide interpretation of results to project teams, senior management, and other stakeholders.
    • Oversee the preparation of nonclinical DMPK/ADME reports and the relevant sections of documents for regulatory submissions.
    • Provide input into the pharmacokinetic and design aspects of nonclinical pharmacology and nonclinical toxicology studies.
    • Partner with AI engineer on ADME predictive model
    • Be a scientific leader and mentor. 

What You Will Bring:

    • A MSc or Ph.D. in Biological Science, Chemistry, Pharmacokinetics, Pharmacology or related discipline with 10+ years Industrial experience in Drug Discovery & Development.
    • Verifiable track record of drug discovery experience, success, and leadership, with experience in advancing programs through all stages of discovery to IND candidates. 
    • Thorough knowledge of FDA and ICH guidelines.
    • Knowledge of various in-vitro & in vivo ADME assays   
    • Ability to work effectively in a dynamic environment with diverse team of coworkers.
    • Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.

What We Offer:

    • Competitive Pay
    • Stock Option Eligibility
    • 401(k) Plan
    • Open PTO Policy
    • Paid Company Holidays
    • Free lunch and snacks at our offices
    • Health Care Plan, including Medical, Dental, and Vision, fully covered for the employees
Genesis Therapeutics is unifying AI and biotech to discover novel and breakthrough treatments for patients with severe and devastating conditions. Genesis was founded on groundbreaking molecular ML research and since has established itself as the industry leader in AI for small molecule drug discovery. Our team of accomplished biotech leaders and expert drug hunters joins forces with deep learning researchers and software engineers who are pioneering predictive and generative AI technologies for molecules.

Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets. 

The company has leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged. In addition, Genesis has two AI platform collaborations across a range of therapeutic areas: Eli Lilly (signed in 2022, with a $20M upfront payment and a $670M total deal size), and Genentech (signed in 2020).
We raised a $200M series B in August 2023, and have raised over $280M in funding from top technology and biotech investors, including Andreessen Horowitz, Rock Springs Capital, T. Rowe Price, Fidelity, Radical Ventures, NVentures (NVIDIA's VC arm), BlackRock, and Menlo Ventures. 

Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.

Finding the best talent is our top priority at Genesis Therapeutics. If you are interested in potential partnership on recruitment, please reach out to