Research Associate - Inhibitor mechanism of action

San Diego, CA /
R&D /
Full-time
Genesis Therapeutics is pioneering artificial intelligence guided rational drug design to address severe unmet medical needs for patients. Our lab in San Diego is recruiting associate scientists with experience in cellular, biochemical or biophysical techniques. Specifically, we are seeking candidates to prosecute plate-based pharmacology, cell culture, enzymology, cell engineering and drug discovery experimental plans for our rapidly advancing pipeline. Education requirements include a bachelor’s or master’s of science with specific focus in one or more of the following disciplines: cell signaling, cell physiology, protein biochemistry, cancer biology and immunology. This is a full-time position in a fast-paced biotech environment with a collegial group of high level colleagues working towards well-defined goals. Full medical and dental benefits, flexible work hours/vacation included in this opportunity to learn all aspects of biotech start-up.

Learn more about us here: https://www.genesistherapeutics.ai/

And our recent collaboration with Eli Lilly here:https://endpts.com/genentech-partnered-genesis-therapeutics-inks-newest-ai-discovery-deal-with-eli-lilly/

Key Responsibilities

    • Discover and develop new small molecule therapeutics for severe disorders in a collaborative research setting.
    • Develop cell lines and disease relevant models for interrogation of mechanism of action studies to support early and late-stage programs.
    • Plan and run assays to study phenotypic response of SAR compounds in cell models to measure anti-proliferative, apoptosis, and cell cycle effects.
    • Perform studies to study target engagement between SAR compounds and proteins in live cells.
    • Perform pharmacodynamics studies for both in-vitro and in-vivo samples to measure protein and mRNA levels.
    • Plan and perform early target validation studies using cDNA, RNAi, CRISPR techniques.
    • Maintain cell lines and models for routine characterization of novel SAR compounds for both 2D and spheroids.
    • Execute immunofluorescence studies to measure protein levels and modifications.
    •  Document findings and record data in electronic notebook.

Qualifications & Experience

    • Bachelor’s or Master’s of Science in related biological discipline.
    • Experience in mammalian cell culture in generating and maintaining reporter cell lines.
    • Understanding of western blot, ELISA, qRT-PCR, and immunofluorescence techniques. 
    • Familiarity with phenotypic assays:  cell growth, apoptosis, and cell cycle.
    • Scientific and technology knowledge of RNAi and CRISPR techniques.
    • Understanding of designing DNA vector constructs for reporters and overexpression mammalian model systems.
    • Familiarity with automate systems and scheduling software.
    • High attention to detail.
    • Strong oral and written communication skills
    • Experience with Graphpad prism, Snapgene, Excel, and Powerpoint.
    • Desired experience with R and python.