Computational Chemist / CADD Scientist

Burlingame, CA /
ML + Software /
Full-time
Genesis Therapeutics is building a world-class computational chemistry team to solve problems in drug discovery through machine learning and biophysical simulation. We are looking for a computational chemist experienced in structure-based drug design to help develop new medicines and play a critical role in building out our software platform.

You will

    • Work directly on multiple small molecule drug discovery programs across a varied target portfolio, including novel targets with little-to-no known chemical matter
    • Utilize off-the-shelf molecular design and simulation tools, as well as custom-built internal tools, to evaluate protein-ligand complexes in 3D
    • Develop structural insights in order to triage small molecule designs output by our ML platform and synthesize those ideas into new, custom molecules
    • Work closely with our software engineering, ML research, and chemistry teams to drive methods development on our ML/MD platform

You are

    • A deep thinker who reasons from first principles, has a strong attention to detail, and has a fiercely pragmatic approach to drug discovery
    • Comfortable working with one-or-more off-the-shelf tools for structure-based drug design, such as MOE, Pymol, and Schrodinger Suite
    • Several years of experience as a computational chemist / CADD scientist at pharma or biotech, driving real-world drug discovery programs forwards with structural insights

What we offer

    • The opportunity to work on high impact tools and products that are immediately deployed to accelerate the discovery of new medicines
    • Strong technical coworkers in AI, software, and chemistry, who all have a powerful mix of intellectual curiosity and humility. The team reads and discusses 1-2 machine learning or chemistry papers every week to stay on top of the field and inspire new ideas
    • Competitive salary and equity. Medical, dental, and vision insurance, and a 401(k) program