(Sr) People Operations Manager

San Diego, CA
G&A /
Full-time /
On-site
We’re looking for a hands-on People Operations Manager focused on building the people functions, reporting to the Head of People at Genesis Therapeutics. In this role, you will be responsible for managing top-tier people programs including total rewards, HR systems and processes, and employment law and compliance. You will work closely with cross-functional teams, including talent acquisition and finance to ensure cohesion across different operational areas.

What You Will Do:


    • Onboarding and Offboarding
    • Continuously improve and streamline seamless employee onboarding and offboarding experiences, partnering with our Admin & People Ops Specialist 

    • Compensation and Benefits 
    • Administer compensation and benefits programs, including merit cycle, equity, and other elements of total rewards
    • Manage benefits plans
    • Support employees in the benefits program, including new employees enrollment, annual open enrollment, and offboarding
    • Administer additional perks, such as ergonomic benefits 

    • HR Policies and Compliance 
    • Review policies and practices to maintain compliance and maintain an up-to-date employee handbook 
    • Ensure compliance with the labor laws and regulations, and completion of mandatory reporting
    • Stay on top of changes in employment laws and regulations, and proactively update HR policies and practices accordingly
    • Administer leaves of absence, including short and long-term disabilities, FMLA, PFL, CFRA, PDL, unemployment claims, and workers’ compensation
    • Serve as the point of contact for immigration-related matters, including visa sponsorships and work permits

    • HR Processes, Systems and Analytics 
    • Drive current state process documentation and discovery
    • Design future state processes in partnership with process owners
    • Building and managing workflows, and partnering with managers to support key employee milestones and moments of recognition, such as review cycles, promotions, equity re-ups, etc
    • Optimizing our people systems to keep them up-to-date and easy to use
    • Develop and manage HR analytics that provide insight into our people matters 

    • Culture and engagement
    • Partner with the Head of People to develop and implement people programs that build employee engagement and retention
    • Promote a culture of collaboration by fostering transparent and inclusive communication with employees

What you’ll bring:

    • Bachelor's degree in Human Resources, Business Administration, or a related field. Master's degree or relevant HR certifications a plus
    • Minimum 5 years of experience across People Operations, with an emphasis on total rewards, compliance, and HR operations and/or HR analytics
    • Experience in a high-growth startup environment is a plus
    • Strong people skills and an ability to connect and support employees at all levels
    • In-depth knowledge of Federal, California, and local labor and regulatory requirements
    • Detailed knowledge and expertise in HR policies and procedures
    • Strong strategic thinking, project management, and decision-making skills. Flexibility to work in an environment with shifting priorities and ambiguity
    • Strong communication skills, critical thinking, and attention to detail
    • We take data seriously; you are a wizard when it comes to HR analytics, and systems / excel proficiency
    • Proficient in HRIS (e.g., Paylocity), ATS, Google Workspace, Microsoft office including Excel, and related software

What we offer:

    • Competitive Pay
    • Stock Option Eligibility
    • 401(k) Plan
    • Open PTO Policy
    • Paid Company Holidays
    • Free lunch and snacks at our offices
    • Health Care Plan, including Medical, Dental, and Vision, fully covered for the employees
$120,000 - $150,000 a year
The salary range for this full-time position is $120K - $150K. In addition, we offer competitive equity and benefits. Within the range, individual pay is determined by work location, level, and additional factors, including relevant skills, experience, and business needs. The base pay range is subject to change and may be modified in the future.
Genesis Therapeutics is unifying AI and biotech to discover novel and breakthrough treatments for patients with severe and devastating conditions. Genesis was founded on groundbreaking molecular ML research and since has established itself as the industry leader in AI for small molecule drug discovery. Our team of accomplished biotech leaders and expert drug hunters joins forces with deep learning researchers and software engineers who are pioneering predictive and generative AI technologies for molecules.

Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets. 

The company has leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged. In addition, Genesis has two AI platform collaborations across a range of therapeutic areas: Eli Lilly (signed in 2022, with a $20M upfront payment and a $670M total deal size), and Genentech (signed in 2020).
We raised a $200M series B in August 2023, and have raised over $280M in funding from top technology and biotech investors, including Andreessen Horowitz, Rock Springs Capital, T. Rowe Price, Fidelity, Radical Ventures, NVentures (NVIDIA's VC arm), BlackRock, and Menlo Ventures. 

Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.



Finding the best talent is our top priority at Genesis Therapeutics. If you are interested in potential partnership on recruitment, please reach out to recruiting@genesistherapeutics.ai.