Scientist - Assay Development

Boston, MA
Foundry: Test
Full-time

Ginkgo is building an industrialized foundry for organism engineering. Our first foundry, Bioworks1, launched in Spring 2015. We designed Bioworks1 to be a single foundry capable of delivering many organisms to customers in many markets. Already, we're using Bioworks1 to concurrently develop 10+ organisms across multiple species and products.

Core to our organism engineering pipeline is the testing and analysis of our engineered strains. We leverage high throughput screens and selections to measure 1000s of strains at a time for improved production of cultured ingredients. As such, your assay development approaches need to work across multiple hosts and cultured ingredients of interest. If successful, your new screening and selection methods will lie at the center of our next foundry Bioworks2.

The ideal candidate has led the development of genetic screens or selections from conception, piloting, development through validation. Experience with screens or selections based on NGS, biosensors or clever genetic selections are of interest.

Responsibilities

    • Develop and validate new HTP screens and selections for cultured ingredients of interest
    • Apply DOE methods to reduce assay CV and increase reproducibility
    • Scale assays to work on 1000s of strains per week via software + automation
    • Develop and validate new assays to screen candidate hosts for pleiotropic traits such as product tolerance and genetic tractability 
    • Collaborate with software engineers to ensure that all generated data is captured, stored and analyzed in Ginkgo's LIMS

Requirements

    • PhD in biology, bioengineering, chemistry, chemical engineering or equivalent or MS with equivalent experience
    • Demonstrated ability to develop genetic screens or selections
    • Familiarity with software or laboratory automation a plus

To learn more about Ginkgo, check out some recent press:

http://www.wired.com/2015/11/move-over-jony-ivebiologists-are-the-next-rock-star-designers/

http://fortune.com/2015/07/23/ginkgo-bioworks/

http://www.fastcompany.com/3053065/most-creative-people/twist-bioscience-inks-deal-to-sell-100-million-pairs-of-synthetic-dna
We also feel it’s important to point out the obvious here – there’s a serious lack of diversity in our industry and it needs to change. Our goal is to help drive that change. We hope to continue to build a company whose culture promotes inclusion and embraces how rewarding it is to work with engineers from all walks of life. Making biology easier to engineer is a tough nut to crack - we can’t afford to leave any talent untapped.

It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.