Senior Computational Biologist & Mammalian Geneticist, Design Team
Boston, MA /
Foundry: Design /
Our mission is to make biology easier to engineer. Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe’s growing challenges in health, energy, food, materials, and more. Our bioengineers make use of an in-house automated foundry for designing and building new organisms. Today, our foundry is developing over 40 different organisms to make different products across multiple industries. Now, our expansion into mammalian cell engineering promises to push our boundaries even further, and so we’re looking for pioneers in this field to make Ginkgo’s new mammalian cell foundry a success.
As a Senior Computational Biologist & Mammalian Geneticist, you’ll support Ginkgo's mammalian cell engineering programs by designing and analyzing high-throughput experiments. You’ll also develop novel computational tools to expand Ginkgo's genetic engineering platform. By adding your own expertise to an interdisciplinary team of bench scientists, computational biologists, data scientists, and software engineers, your role will be critical in helping Ginkgo to develop world-changing tools to engineer biology.
Please note: we recognize that not all candidates may meet the entire list of Desired Experience and Capabilities. We’re eager to train the right candidates for this role, and encourage those who meet at least two-thirds of the criteria to apply.
- Integrate internal and external data to establish the technical vision and initial development of mammalian-focused computational biology tools.
- Troubleshoot moderate- to high-complexity technical problems, proposing biological design solutions in the dry lab, and maintaining familiarity with protocols (e.g. cell culture, diagnostic/QC assay design, and execution) in the wet lab.
- Support Ginkgo’s organism engineering teams with your expertise in mammalian genetics, designing megabases of DNA for each project.
- Collaborate with stakeholders across Ginkgo to create next-generation synthetic biology tools (e.g. algorithms, data structures, predictive models, software pipelines, and/or experimental approaches) that yield step changes in our ability to engineer mammalian cell lines.
- Maintain high-quality documentation of your work and discoveries, creating written reports, technical presentations, electronic lab notebooks, internal database records, code comments, and software documentation.
Desired Experience and Capabilities
- PhD (or equivalent experience) in mammalian genetics, genomics, systems biology, biochemistry, computational biology, quantitative biology, or other relevant field. Interdisciplinary work is strongly encouraged.
- 2+ years of professional experience (grad school counts) working with mammalian genome engineering tools, such as CRISPR/Cas systems, recombinases, and viral vectors. Engineering additional organisms, such as yeasts or microbes, are preferred but not essential.
- Experience with functional genomics screens involving CRISPRi/a and/or shRNA libraries.
- Proficiency with at least one software programming language (Python preferred). Knowledge of best practices for collaborative software development (version control systems, test-driven development, and good documentation habits) is preferred.
- First-hand technical experience in at least two of the following areas: bioinformatics, sequence analysis, genomics, NGS analysis, statistics, probabilistic modeling, machine learning, metabolic engineering, and quantitative modeling of biological systems.
- Prior experience in technical leadership, project management, and/or direct management of a 2–4 person team.
- Demonstrated ability to meet the demands of multiple concurrent projects.
- Strong curiosity about (and comfort working in) areas of biology previously unknown to you and, at times, your peers.
To learn more about Ginkgo, check out some recent press:
Ginkgo Bioworks Provides Support on Process Optimization to Moderna for COVID-19 Response (PRNewswire)
The Life Factory: Synthetic Organisms From This $1.4 Billion Startup Will Revolutionize Manufacturing (Forbes)
We also feel it’s important to point out the obvious here – there’s a serious lack of diversity in our industry and it needs to change. Our goal is to help drive that change. Ginkgo is deeply committed to diversity, equality, and inclusion in all of its practices, especially when it comes to growing our team. We hope to continue to build a company whose culture promotes inclusion and embraces how rewarding it is to work with engineers from all walks of life. Making biology easier to engineer is a tough nut to crack – we can’t afford to leave any talent untapped.
It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees and employment applicants.