Laboratory Technician/ Research Associate, Process Development

South San Francisco /
CMC /
Full-Time
Graphite Bio is a clinical-stage biotechnology company focused on harnessing the power of targeted DNA integration. Graphite Bio uses next-generation CRISPR based technology platforms for developing curative gene correction-based stem cell therapies for serious and life-threatening genetic diseases with inadequate existing treatment options

The Role:

The Laboratory Technician/ Research Associate, Process Development will be responsible for supporting all process development activities beginning at Graphite Bio for both pipeline programs as well as process optimization for clinical candidates. The Laboratory Technician will work on all activities in collaboration with technical stakeholders within the CMC Process Development group at Graphite Bio.

What You Will Do:

    • Provide operational support for the development of processes for complex cell and gene therapies using gene editing methods like CRISPR/Cas9
    • Perform analytical testing using methods like flow cytometry, ddPCR and CFU assays during development and scale up runs
    • Perform flow cytometry, ddPCR, CFU and other such assays for in-house development products and incoming materials as needed
    • Perform hands on mammalian cell culture using primary hematopoietic stem cells derived from leukopaks as well as certain mammalian cell lines
    • Perform cell isolations using the CliniMACS Plus and CliniMACS prodigy system and cryopreserve cells for cell bank generation
    • Maintain supply inventory and ensure continuous supply of reagents and equipment specific materials
    • Maintain LN2, freezer and refrigerator inventory
    • Assist with procurement, maintenance, set up and installation of laboratory equipment
    • Write technical documents including laboratory procedures and technical reports

What You Will Bring

    • Bachelor’s or Associate’s Degree in biology or related field
    • Experience with mammalian cell culture and PCR is highly desired
    • Experience working in a biological laboratory environment in academia or industry
    • Excellent teamwork and collaboration skills
    • Outstanding written and verbal communication skills
    • Ability to organize and multi-task as needed in a start-up environment
Fit with Graphite Bio’s culture:
Ability to build strong relationships with co-workers of various backgrounds and expertise
Ability to function at a high level in a team setting whether leading the group or acting as an individual
contributor
Values-based leadership consistent with Graphite Bios’ Core Values
Excitement about the vision and mission of Graphite Bio 
Flexibility
Integrity

Compensation/ Benefits:
Competitive salary with equity 
Health benefits

Graphite Bio is an equal opportunity employer, and all qualified applicants will receive consideration for
employment without regard to age, race, color, religion, sex, sexual orientation, gender identity, national
origin, protected veteran status, or disability status, or any other characteristic protected by law.