Senior Scientist, Biomarker Assay

South San Francisco /
Research /
Full-Time
Graphite Bio is a clinical-stage biotechnology company focused on harnessing the power of targeted DNA integration. Graphite Bio uses next-generation CRISPR based technology platforms for developing curative gene correction-based stem cell therapies for serious and life-threatening genetic diseases with inadequate existing treatment options

The Role:
We are seeking an outstanding Senior Scientist to join the Translational Science team.  This role will be responsible for driving the development, execution, and data analysis of exploratory biomarker assays for Graphite Bio’s clinical pipeline.Wah

What You Will Do:

    • Provide scientific and strategic insight to develop novel biomarker assays to support MOA, efficacy, and differentiation of Graphite Bio programs
    • Design, develop, and validate biomarker assays to advance clinical development of Graphite Bio’s novel gene editing platform
    • Conduct clinical testing using established biomarker/translational assays to support Graphite Bio clinical studies 
    • Establish and maintain Graphite Bio’s Biomarker Laboratory in partnership with Director of Translational Science to ensure cleanliness, safety, adequate inventory, and required quality documentation for instruments and materials
    • Write and review SOPs and facilitate assay transfer to different teams or external CROs.
    • Manage external CROs for biomarker assay transfer and/or development. 
    • Train and manage biomarker assay scientists
    • Review and analyze assay data for assurance of assay quality and consistency.
    • Report and present PD/biomarker data to cross-functional project teams and other internal and external stakeholders 
    • Ensure high-quality documentation for regulatory submissions and publications. 


What You Will Bring:

    • Provide scientific and strategic insight to develop novel biomarker assays to support MOA, efficacy, and differentiation of Graphite Bio programs
    • Design, develop, and validate biomarker assays to advance clinical development of Graphite Bio’s novel gene editing platform
    • Conduct clinical testing using established biomarker/translational assays to support Graphite Bio clinical studies 
    • Establish and maintain Graphite Bio’s Biomarker Laboratory in partnership with Director of Translational Science to ensure cleanliness, safety, adequate inventory, and required quality documentation for instruments and materials
    • Write and review SOPs and facilitate assay transfer to different teams or external CROs.
    • Manage external CROs for biomarker assay transfer and/or development. 
    • Train and manage biomarker assay scientists
    • Review and analyze assay data for assurance of assay quality and consistency.
    • Report and present PD/biomarker data to cross-functional project teams and other internal and external stakeholders 
    • Ensure high-quality documentation for regulatory submissions and publications. 

Fit with Graphite Bio’s culture:
Ability to build strong relationships with co-workers of various backgrounds and expertise
Ability to function at a high level in a team setting whether leading the group or acting as an individual
contributor
Values-based leadership consistent with Graphite Bios’ Core Values
Excitement about the vision and mission of Graphite Bio 
Flexibility
Integrity

Compensation/ Benefits:
Competitive salary with equity 
Health benefits

Graphite Bio is an equal opportunity employer, and all qualified applicants will receive consideration for
employment without regard to age, race, color, religion, sex, sexual orientation, gender identity, national
origin, protected veteran status, or disability status, or any other characteristic protected by law.