Clinical Biomarkers Lead - Autoimmunity
Mountain View, CA /
Clinical Research & Development – Clinical Biomarkers/Clinical Biosample Operations /
Full-Time
/ Hybrid
About IGM Biosciences, Inc.
IGM Biosciences (Nasdaq: IGMS) is a clinical-stage biotechnology company committed to developing and delivering a new class of medicines to treat patients with cancer, infectious diseases, and autoimmune and inflammatory diseases. The Company’s pipeline of clinical and preclinical assets is based on the IgM antibody, which has 10 binding sites compared to conventional IgG antibodies with only 2 binding sites. We have created a proprietary IgM antibody technology platform that we believe is particularly well suited for developing T cell engagers, receptor cross-linking agonists, targeted cytokines, and target neutralizers. The Company also has an exclusive worldwide collaboration agreement with Sanofi to create, develop, manufacture, and commercialize IgM antibody agonists against oncology and immunology, and inflammation targets. For more information, please visit www.igmbio.com.
IgM Antibodies and Autoimmune and Inflammatory Diseases
Antibody treatments have revolutionized outcomes for patients with autoimmune and inflammatory diseases, and IgMs are the first antibody defense against a pathogen infection. We are committed to exploring how the unique structure and binding properties of our IgM platform can improve outcomes for patients with these serious conditions.
IgM Antibodies and Oncology
IGM Biosciences has a T cell engager program, a receptor cross-linking agonist program and a targeted cytokine program in clinical studies for the treatment of patients with solid tumors and hematological malignancies.
Clinical Biomarkers Lead-Autoimmunity
We are seeking a dynamic and experienced Clinical Biomarkers Lead to join the Clinical Research and Development Group at IGM Biosciences to drive biomarker and drug development efforts for our clinical programs in autoimmunity. The optimal candidate will have a strong scientific background, curiosity and creativity, experience leading and executing on autoimmunity or immunology-focused programs, have a strong drive to succeed, and work well with other research, translational, and clinical scientists.
Responsibilities:
The successful candidate will have oversight for one or more clinical biomarker programs. Responsibilities include translating preclinical hypothesis into clinical biomarker strategies, generating and analyzing diverse biomarker data to derive scientific insights, validating these insights with experimental approaches and translating them into development/diagnostic opportunities. The incumbent will also be expected to have a thorough understanding of disease and drug target biology and provide disease area biomarker expertise, and collaborate with discovery research and clinical development groups, as well as key external investigators and opinion leaders. Effective communication is essential and includes presenting at cross-functional teams and external conferences, as well as writing biomarker sections of clinical protocols, reports, regulatory filings, and scientific publications.
Requirements:
· PhD, MD or PhD/MD degree in a relevant scientific field (e.g., immunology, molecular biology) and 3+ years industry experience in clinical biomarkers and drug development.
· A deep understanding of human immunology and preclinical immune-related disease models is required, along with the ability to distill complex issues and clearly articulate solutions, and ability to develop hypotheses and direct analysis plans.
· Knowledge and/or experience in translational research, human immune response assessments, and molecular assays, including cutting edge multi-omics technologies such as NGS, multiplex IHC/IF, high dimensional flow cytometry, and single cell RNASeq.
· Key aspects for this position will be the analysis of large datasets and experience integrating biomarkers into clinical trials to enable decision making. Familiarity and/or experience with big data analytics tools such as R, Python, Partek flow, Spotfire, or other data analysis programming is desirable.
· Independent and creative scientist with successful demonstration of initiative and leadership/collaboration within cross-functional teams.
· Outstanding presentation and communication skills, including strong writing skills, as evidenced by publications, meeting abstracts and/or drug development reports.
The typical annual salary range for this full-time position is $140,000 - $185,000, plus eligibility for cash and equity incentives.
This range reflects the characteristics of the job, such as required skills and qualifications, and is based on the office location noted in this job posting. The range may also be adjusted based on the applicant's geographic location.
Actual individual pay is determined by demonstrated experience and internal equity alignment.
We offer a fast-paced, collaborative, team-based, work environment.
One of our top priorities is to maintain the health and well-being of our employees and their families. To achieve this goal, we offer comprehensive benefits with a variety of options:
· Medical, dental and vision insurance.
· The full premium amount for our employees and their dependents is covered by IGM
· FSA (Flexible Spending Account)
· STD, LTD, Basic Life and AD&D Insurance, Supplemental Life and AD&D Insurance
· 401(k) Plan
· 120 hours of Paid Time Off, 5 sick days per year, 11 holidays
· Cell phone & internet subsidy
· Employee Referral Bonus Program
· Annual training budget for professional development
· Commuter Benefit
· Annual bonus program
· New hire stock options
IGM is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status. All qualified applicants will receive consideration for employment.
