Associate Scientist / Scientist I, Protein Sciences
B1 - CA, MV
Process Development & Manufacturing – Process Development /
Full-Time /
On-site
About IGM Biosciences, Inc.
IGM Biosciences (Nasdaq: IGMS) is a clinical-stage biotechnology company committed to developing and delivering a new class of medicines to treat patients with cancer and autoimmune and inflammatory diseases. The Company’s pipeline of clinical and preclinical assets is based on the IgM antibody, which has 10 binding sites, compared to conventional IgG antibodies with only 2 binding sites. We have created unique IgM antibodies with high selectivity, affinity, and avidity that may redefine what is possible for therapeutic antibody medicines. We believe our proprietary IgM antibody technology platform is particularly well suited for developing T cell engagers and receptor cross-linking agonists. The Company also has an exclusive worldwide collaboration agreement with Sanofi to create, develop, manufacture, and commercialize IgM antibody agonists against oncology, immunology, and inflammation targets. For more information, please visit www.igmbio.com.
IgM Antibodies and Autoimmune and Inflammatory Diseases
Antibody treatments have revolutionized outcomes for patients with autoimmune and inflammatory diseases. We are committed to exploring how our IgM antibody platform's unique structure and binding properties can improve outcomes for patients with these serious conditions.
IgM Antibodies and Oncology
The potential of our IgM antibodies drives our focus on oncology. Leveraging the power of avidity and the strong and durable binding of our IgM antibodies, we are developing new treatment options for cancer patients. Our initial efforts in this field are centered around the broad application of IgM antibodies to activate receptors, triggering the programmed death of cancer cells.
Our Protein Sciences group is looking for an Associate Scientist or Scientist I (lab-based role) with a background in protein chemistry to play an essential role in the purification and characterization of antibodies and recombinant proteins for research and development purposes. You will utilize your expertise in protein purification techniques to purify antibodies and other proteins of interest, ensuring high yield and purity. You will also analyze and characterize the purified proteins to ensure they meet project specifications. You will have the opportunity to present your data in internal and external meetings.
Responsibilities:
- Perform protein purification using AKTA systems and various chromatographic techniques (affinity, ion exchange, size exclusion chromatography, etc.)
- Develop and implement efficient and scalable protein purification strategies for diverse proteins (including different antibody isotypes and recombinant proteins)
- Analyze the purity of purified proteins using techniques such as SDS or native PAGE, CE, SEC-HPLC, MALS
- Maintain lab equipment and prepare reagents and buffers
- Troubleshoot purification processes, develop and optimize protocols to improve yield and purity
- Collaborate with colleagues across the organization to ensure successful project completion
- Follow safe laboratory practices and maintain accurate and detailed laboratory notebooks/electronic records/SOPs (experience with Benchling is a plus)
- Stay current with the latest advancements in protein purification techniques
- May provide training and guidance to junior staff members
Qualifications:
- Level commensurate with experience.
- Degree in Biochemistry, Protein Chemistry, Chemistry or a related field
- BS + 11 years or MS + 6 years (Associate Scientist) in protein purification or Ph.D. with up to 2+ years experience (Scientist I)
- Strong working knowledge of various protein purification techniques
- Excellent problem-solving and troubleshooting skills is a must
- Strong organizational skills and the ability to manage multiple tasks simultaneously
- strong communication skills, and attention to detail
- Experience with antibody analytics and one or more of the following techniques: ELISA, HPLC, SEC-MALS, SLS/DLS is preferred
- Experience with automation and high throughput purification using Hamilton, Tecan, or equivalent technology is a plus.
- Experience with AKTA Pure or AVANT is a plus
$110,000 - $140,000 a year
This range reflects the characteristics of the job, such as required skills and qualifications, and is based on the office location noted in this job posting. The range may also be adjusted based on the applicant's geographic location.
Actual individual pay is determined by demonstrated experience and internal equity alignment.
One of our top priorities is to maintain our employees' and their families' health and well-being. To achieve this goal, we are offering robust and comprehensive benefits with a variety of options:
· Medical, dental, and vision insurance. IGM covers the full premium amount for our employees and their dependents.
· FSA (Flexible Spending Account) or HSA (Health Savings Account)
· STD, LTD, Basic Life and AD&D Insurance, Supplemental Life and AD&D Insurance
· 401(k) Plan with Employer Match
· 3 weeks Paid Time Off, 5 sick days per year, 12 holidays
· Annual bonus program
· New hire equity and performance-based annual refresh grants
· ESPP (Employee Stock Purchase Plan)
· Cell phone or internet subsidy
· Employee Referral Bonus Program
· Annual training budget for professional development
· Commuter Benefit
· Pet Insurance
IGM is an equal opportunity employer that prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status. All qualified applicants will be considered for employment.
