Scientist - Genome Editing

San Francisco /
R&D - Genome Editing & Protein Discovery – Genome Editing and Protein Discovery /
Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to democratize disease detection with an easy and affordable point-of-care test that allows real-time and simultaneous detection of multiple conditions. By leveraging its internal research and development and exclusive licensing to Cas12, Cas13 and Cas14, Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Mayfield, NFX, and 8VC, Decheng and leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

Mammoth is seeking a Scientist with expertise in genome editing in cultured mammalian cells. The ideal candidate will have direct experience developing CRISPR systems; a strong background in genome editing and/or genome modulation in mammalian cells is essential. Candidates must be comfortable collaborating with others and prioritizing time, agendas, and projects to accomplish goals. 


    • Initiate, direct, and perform experiments to advance the application of newly discovered CRISPR systems in mammalian cells
    • Develop CRISPR systems for genome editing
    • Interface with protein screening and biochemistry teams
    • Manage direct reports and collaborate with others on the team
    • Stay current in the field by participating in educational opportunities and reading relevant publications.
    • Think creatively about genome editing technologies


    • Ph.D. in relevant field with 3+years relevant experience
    • Strong background in tissue culture, molecular biology and cell engineering
    • Demonstrated experience with CRISPR in primary human cells using AAV and/or RNP delivery
    • Strong communication, presentation and data analysis skills
    • Highly motivated and detail-oriented individual with the ability to think creatively

Preferred Qualifications

    • Experience with CRISPR spacer screens
    • Experience with NGS to characterize CRISPR editing outcomes and off-targets
    • Experience working with primary cells
    • Experience with viral vector delivery such as AAV
    • Liquid handling automation experience


    • Competitive salary with equity
    • Full health/vision/dental benefits
    • Unlimited vacation
    • Free breakfast/lunch/dinner/barista
    • Free gym
    • Public transportation commuter subsidy
    • 401(k) matching