Scientist, Analytical Chemistry

South San Francisco /
R&D - Diagnostics – R&D - Diagnostics /
Full-Time
COMPANY
Mammoth Biosciences, Inc. is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and CasPhi, Mammoth Biosciences can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Mammoth is democratizing disease detection with easy and affordable point-of-care tests that allow real-time and simultaneous detection of multiple conditions, along with high-throughput tests that allow for unprecedented testing volume. Further, the company is transforming disease treatment with its proprietary micro-sized CRISPR proteins that enable new editing and delivery options. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Prize winner Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber. 

OPPORTUNITY
The qualified candidate will take an active role in supporting diagnostic reagents development by applying a variety of analytical methodologies to support physical and chemical characterization of raw materials such unique Cas enzymes and reagent formulations. The individual will be responsible for performing laboratory work in support of analytical testing of diagnostic projects, and will have relevant experience with the following analytical methodologies: chromatography, dissolution, KF, particle size will be desirable.

KEY RESPONSIBILITIES

    • Reagents formulation development and technology transfer
    • Analytical method development and validation using a variety of technologies including HPLC, LC-MS, GC, GC/MS, Microscopy, FTIR and UV-Vis 
    • Stability and release testing; testing to support formulation development efforts
    • Calibrate, maintain and operate laboratory equipment such as HPLC, GC, LC-MS,, UV-Vis, pH meter, balances, KF, DSC
    • Direct interaction with project team members, including presentation of data and critical review of data
    • Preparation of technical reports and evaluation of new instrumentation or analytical technique
    • Communicate effectively with clients and internally through written and oral presentation
    • Ensure compliance with government rules and regulations (FDA, cGMP, OSHA, etc.)
    • Work with broad objectives and be independent on a daily basis
    • Supervision of junior scientists
    • Analyze data from the qualitative to the rigorously statistical and defending conclusions based on data

REQUIRED QUALIFICATIONS

    • Bachelor’s degree and 10 years of industry experience, master’s degree with 5 years if industry experience, or PhD with 3 years of industry experience
    • Expertise in one or more of the following: HPLC, LCMS, GC, NMR from method development to validations and troubleshooting
    • Knowledge of analytical equipment/instruments such as HPLC, GC, LCMS, FTIR, UV-Vis, pH meter, KF, DSC, TGA, NMR
    • Working knowledge in analytical method development and validation in the regulatory environment (FDA, cGMP, etc)
    • Experience in molecular assay and reagent development

PREFERRED QUAILIFICATIONS

    • Strong organizational skills
    • Ability to multitask
    • Effective interpersonal and communication skills 
    • Experience in DOE methodologies
    • Experience QC method development and tech transfer
    • Experience in enzyme/protein kinetics

BENEFITS

    • Competitive salary with equity
    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Free breakfast/lunch/dinner/barista
    • Wellness, caregiver and ergonomics stipends
    • 401(k) matching