Lead Project Manager (CRISPR therapeutics)

Mammoth Brisbane, CA
2100 - R&D – R&D /
Full-Time /
Mammoth Biosciences has an opening for a Lead Project Manager (PM) who will manage our growing CRISPR-based Therapeutics programs as we bring them to market.  The Project Manager will be responsible for planning, oversight, and management of projects from Gene Editing Technology Development through Therapeutics Drug Development in collaboration with internal technical teams, external service providers and our strategic partners.  The Lead PM will partner with the Program Technical Lead to coordinate all internal and external team deliverables to ensure that project commitments are met.  This role will report into the Sr Director or Director of Program Management.


    • Collaborate with Program Technical Leader and cross-functional team members to establish a development strategy ensuring linkage between strategic and operational activities
    • Manage matrixed project teams through the application of PM skills in resource planning, timeline development, stakeholder management, risk/issue management, finance, and budget planning
    • Design, communicate and implement project plans in Smartsheet to ensure projects are completed on time and within budget
    • Monitor progress of projects against plan. Define and collect metrics to track project progression and measure key deliverables
    • Highlight project risks and facilitate problem-solving, contingency planning, and decision-making to resolve problems and minimize delays
    • Coordinate and ensure cross-department communication and integration by leveraging cross-functional relationships to ensure seamless coordination and responsiveness
    • Establish regular communications to share information and updates with internal and external stakeholders throughout the duration of projects
    • Consolidate program metrics to support portfolio progress reporting
    • Ensure senior management approval of changes to scope, budget or timelines
    • Develop and execute project plans by coordinating with operations across various functional areas
    • Provide updated project documents and information for regular program and budget updates


    • Bachelor’s degree in Biological Sciences, Bioengineering, Chemistry or an associated scientific discipline with a minimum of 7+ years of project management experience in the life sciences industry (masters with 5+ years of experience)
    • Solid understanding of pharmaceutical product development phases and the role that key functions play (e.g. Research, CMC, NonClinical/Clinical Development, Regulatory) with a strong emphasis on early stage to IND/CTA
    • Demonstrated proficiency in project management tools e.g. MS Project, SmartSheet, advanced Excel abilities
    • Ability to work onsite a minimum of 3 days per week


    • Proven experience in project or program management within the biotech/pharma industry - preferred experience managing projects in Gene Editing or Gene/Cell Therapy
    • Certification (PMP) or formal training in Project Management and experience using project management and resource management tools
    • Effective communication skills with cross functional teams, key stakeholders and senior leadership
    • Establish, maintain, and lead high performing project teams 
    • Ability to hold team members, partners and vendors accountable to execute projects on time and within budget
    • Understanding of the requirements of key regulatory deliverables in Europe and the U.S. to drive successful outcomes from a program management perspective
    • Exceptional interpersonal and leadership skills to effectively communicate and build relationships at all levels within the organization 
    • Exceptionally organized and process driven
    • Influencer capable of balancing consensus perspectives and cohesive decisions
    • Leverages a data-driven and structured approach to facilitate decision making
    • Ability to operate in a fast-paced, multi-disciplinary biotech environment
    • Demonstrated ability to adapt to new situations and learn quickly
    • Six-sigma green belt certification with practical experience of implementation


    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Company-sponsored meals and snacks
    • Wellness, caregiver and ergonomics benefits
    • 401(k) with company matching
Base Salary Range: $167,580 - $182,000

The listed base salary range is for Mammoth employees in the Bay Area. Actual base salary will be determined by geographic work location, relevant professional experience, applicable skills, and internal equity. The base salary range for those working remotely outside of the San Francisco Bay Area may differ and will be determined by industry market data for the role and specific region

Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.