Senior Research Associate - Plasmid Process Development

Mammoth Brisbane, CA
2100 - R&D – R&D /
Full-Time /
Join Mammoth, a leading biotechnology company at the forefront of CRISPR-based technology development, as a Senior Research Associate in Plasmid Process Development. You'll have the opportunity to contribute to groundbreaking research and development efforts, designing and producing plasmids to support our innovative therapeutics and diagnostics. This role offers the chance to work in a dynamic and collaborative environment, leveraging your expertise in molecular biology and process development to make a significant impact on the future of healthcare. If you're passionate about harnessing the power of CRISPR for real-world applications, apply now to be part of our pioneering team.


    • Design and construct plasmids for various applications using molecular biology techniques
    • Develop and optimize in-house processes for plasmid production, purification, and quality control
    • Perform hands-on laboratory work to produce plasmids at scale, ensuring consistency and quality
    • Collaborate with cross-functional teams to support the development of CRISPR-based therapeutics and diagnostics
    • Troubleshoot and resolve issues related to plasmid production and purification processes
    • Implement and maintain documentation of standard operating procedures (SOPs) and batch records
    • Stay current with advancements in plasmid design, production, and purification techniques


    • Bachelor's or Master's degree in Molecular Biology, Biochemistry, Biotechnology, or related field
    • Minimum 2 years of experience in plasmid design, production, and purification in an industrial or academic setting
    • Proficiency in molecular biology techniques such as PCR, cloning, and DNA sequencing
    • Experience with various methods of plasmid purification, including column chromatography and ultrafiltration
    • Strong analytical and problem-solving skills
    • Excellent communication and interpersonal skills, with the ability to work collaboratively in a team environment


    • Experience in mRNA or AAV drug development and/or platform development
    • Experience with CRISPR-based technologies is highly desirable 
    • Knowledge of GMP/GLP regulations
    • Familiarity with automation and high-throughput techniques for plasmid production
    • Experience in scaling up production processes for commercialization
    • Publication record demonstrating expertise in plasmid design and production


    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Company-sponsored meals and snacks
    • Wellness, caregiver and ergonomics benefits
    • 401(k) with company matching
Base Salary Range: $100,000 - $108,000

The listed base salary range is for Mammoth employees in the Bay Area. Actual base salary will be determined by geographic work location, relevant professional experience, applicable skills, and internal equity. The base salary range for those working remotely outside of the San Francisco Bay Area may differ and will be determined by industry market data for the role and specific region.

Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against Covid-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.