Scientist - Biochemistry/Protein Discovery

San Francisco
Gene Editing and Protein Discovery
Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to democratize disease detection with an easy and affordable point-of-care test that allows real-time and simultaneous detection of multiple conditions.  By leveraging its internal research and development and exclusive licensing to Cas12, Cas13 and Cas14, Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Mayfield, NFX, and 8VC, Decheng and leading individual investors including Brook Byers, Tim Cook, and Jeff Huber. 

Mammoth is seeking a Scientist with expertise in protein biochemistry. The ideal candidate will have direct experience studying newly-discovered CRISPR systems and their applications. A strong background RNA biochemistry and protein engineering is a plus. Further, the ideal candidate will be comfortable leading and managing others, including prioritizing time, agendas, and projects to accomplish goals.


    • Initiate, direct, and perform experiments to advance the application of newly-discovered CRISPR systems
    • Develop high-throughput biochemical experiments 
    • Optimize components to enhance CRISPR function
    • Stay current in the field by participating in educational opportunities and reading relevant publications
    • Think creatively about the biochemistry of genome editing technologies


    • Ph.D. in relevant field with 3+ years relevant research experience
    • Experience with high throughput biochemical and bacterial screens 
    • Background in protein biochemistry and/or nucleic acid biochemistry
    • Exceptional communication, presentation, and data analysis
    • Excited about working in a diverse and collaborative team

Preferred Qualifications

    • Experience with directed evolution and rational design based protein engineering projects
    • High throughput screening of nucleases
    • Experience with NGS
    • Liquid handling automation experience


    • Competitive salary with equity
    • Full health/vision/dental benefits
    • Unlimited vacation
    • Free breakfast/lunch/dinner/barista
    • Free gym
    • Public transportation commuter subsidy
    • 401(k) matching