Principal Mechanical Engineer

Mammoth Brisbane /
R&D - Diagnostics – R&D - Diagnostics /
Mammoth Biosciences, Inc. is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and CasPhi, Mammoth Biosciences can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Mammoth is democratizing disease detection with easy and affordable point-of-care tests that allow real-time and simultaneous detection of multiple conditions, along with high-throughput tests that allow for unprecedented testing volume. Further, the company is transforming disease treatment with its proprietary micro-sized CRISPR proteins that enable new editing and delivery options. Based in Brisbane, CA, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Prize winner Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber. 

Mammoth is seeking a Principal Mechanical Engineer with expertise in instrumentation and consumable designs. You will work in a diverse, dynamic, multifunctional team to package our novel CRISPR enzymes into a molecular diagnostics system. The successful candidate will have experience in bringing products from concept to production. The position will require creativity and outside-of-the-box thinking with strong technical and analytical skills.


    • Manage all aspects of mechanical engineering projects from concept through detailed design, prototyping, and verification/validation testing
    • Design electromechanical subsystems involving fluidics, microfluidics, thermal cycling, and optics
    • Perform engineering calculations and simulations as necessary to support design decisions
    • Review and provide feedback on mechanical designs from external engineering teams
    • Transfer product from development to manufacturing
    • Estimate costs, timelines, and budgets for new designs
    • Manage Solidworks and PDM


    • Bachelor’s degree in an engineering-related discipline
    • 10 years of professional mechanical engineering experience
    • Extensive experience with SolidWorks
    • Experience with FEA analysis of mechanical components (thermal, stress, fluidics)
    • Demonstrated experience designing, prototyping, and testing mechanical assemblies
    • Proficiency with GD&T and tolerance analysis


    • Experience working in the medical device industry
    • Basic project management skills and ability to hold to a project timeline
    • PDM administrative experience
    • Electromechanical and fluidics experience
    • Ability to function in a fast-paced small company environment with minimal direction and ability to adjust workload based upon changing priorities
    • Ability to think critically with demonstrated troubleshooting and problem-solving skills
    • Excellent interpersonal, verbal, and written communication skills


    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Company-sponsored meals and snacks
    • Wellness, caregiver and ergonomics benefits
    • 401(k) with company matching
It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law.  This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.