Scientist, Therapeutic Genome Editing

Mammoth Brisbane /
R&D - Genome Editing & Protein Discovery – Genome Editing and Protein Discovery /
Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through metagenomics discovery and development of novel and proprietary CRISPR systems, the company is enabling innovative diagnostics and revolutionary medicines. Based in Brisbane, CA, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna. At Mammoth, we are passionate about transforming lives through innovation.

Mammoth is seeking a Scientist with expertise in therapeutic genome editing. The ideal candidate will have direct experience developing CRISPR systems; a strong background in genome editing and/or genome modulation in primary cells and disease models. Candidates must be comfortable collaborating with others and prioritizing time, agendas, and projects to accomplish goals. 


    • Initiate, direct, and perform experiments to evaluate novel genome editing systems
    • Advance the application of novel CRISPR systems for human therapeutics
    • Manage direct reports and collaborate with others on the team
    • Record, document, analyze and communicate scientific data to senior staff and team members and participate in the writing of SOPs, report, and manuscripts for publications


    • Ph.D. in relevant field with 3+ years relevant experience
    • Strong background in molecular biology, cell engineering, gene and cell therapy
    • Experience with genome editing for human therapeutics
    • Experience with viral and/or non-viral delivery methods (such as AAV and LNP)


    • Demonstrated expertise with CRISPR for human therapeutics
    • Experience with characterization and optimization of CRISPR systems
    • Experience working with primary cells, iPSC and complex cell culture systems
    • Experience with AAV vector optimization and production
    • Experience with NGS to characterize CRISPR editing efficiency and specificity
    • Strong communication, presentation and data analysis skill


    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Company-sponsored meals and snacks
    • Wellness, caregiver and ergonomics benefits
    • 401(k) with company matching