Director of Genome Editing

San Francisco /
Genome Editing and Protein Discovery /
Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through the discovery and development of novel CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to democratize disease detection with an easy and affordable point-of-care test that allows real-time and simultaneous detection of multiple conditions. By leveraging its internal research and development and exclusive licensing to Cas12, Cas13 and Cas14, Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Mayfield, NFX, and 8VC, Decheng and leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.

Mammoth is seeking a Director of Genome Editing to lead a team that will continue to develop newly-discovered CRISPR systems in mammalian cells. Direct experience with CRISPR and its applications is essential. The ideal candidate must also be comfortable managing others, including setting goals for the team, designing experiments and monitoring progress.


    • Interface with external partners and other teams
    • Set goals and priorities for team
    • Design overall experimental strategy in collaboration with team
    • Continue to build team and support team members in their career growth
    • Work with CSO to set company objectives


    • Ph.D. in relevant field with 3+ years relevant research experience 
    • 3+ years of management experience
    • Strong background in tissue culture, molecular biology and cell engineering
    • Demonstrated track record working with CRISPR in primary human cells using AAV and/or RNP delivery
    • Exceptional communication, presentation, and data analysis
    • Have exceptional interpersonal skills and previous experience managing direct reports


    • Competitive salary with equity
    • Full health/vision/dental benefits
    • Unlimited vacation
    • Free breakfast, lunch, dinner, and barista
    • Free gym
    • Public transportation commuter subsidy
    • 401(k) matching