Scientist I/II - In Vivo/In Vitro Cell Biologist

Cambridge, MA
Cell Biology /
Full-Time /
About Us
Our mission is to develop transformational genetic medicines utilizing novel delivery technologies, with an emphasis on diseases with significant unmet medical need. Our team is advancing multiple innovative approaches to deliver a variety of therapeutic payloads, focusing initially on gene editing in therapeutically relevant cells and tissues. Our world class scientific founders include Professor David Liu (HHMI, Broad and Harvard) and Professor Keith Joung (Arena BioWorks, formerly MGH), and we are funded with a significant capital investment by leading life science venture capital firms including Newpath Partners, Atlas Venture, F-Prime Capital, and 5AM Ventures. We believe that our technology has the potential to positively impact patients suffering from severe genetic diseases, and we are committed to building an excellent, science-driven and diverse team that is passionate about making a difference. Nvelop Therapeutics is based in Cambridge, MA.

Position Overview
We are seeking a talented and growth-oriented Scientist I/II to join our In vivo/Cell Biology team. The successful candidate will lead in vivo studies to include study design, animal ordering, perform dosing of mice, harvest, and processing of tissues, immunophenotyping and lead PK/PD efforts.

This individual will join a multidisciplinary team of scientists and contribute to a collaborative and fast-paced environment. The successful candidate will help build a first-class in-vivo/in-vitro preclinical and translational group and establish core capabilities for characterizing non-viral drug delivery vehicles.

The ideal candidate will have strong hands-on experience with relevant in vivo models including a variety of procedures and techniques such as animal manipulation and dosing, necropsy, ex vivo tissue dissociation, primary cell culture, and multicolor flow cytometry experience or curiosity to learn.  The ideal candidate will have the capability and desire to learn and apply new experimental methodologies, drive to execution, experimental rigor, and scientific curiosity! We are a small and growing company, so the ability to work in a fast-paced environment and adapt to evolving priorities is a must.

Job Responsibilities:

    • Significantly contribute to in vivo study methodologies including dose preparation of test articles, IV/RO injections, retro-orbital blood sampling, necropsy at EOS.
    • Work closely with the in vivo pharmacologist aspects of multiple projects within discovery and development.
    • Propose, plan, coordinate, and supervise study execution at external Contract Research Organizations (CROs).
    • Develop and implement new animal models to improve in vivo pharmacology studies.
    • Write Institutional Animal Care and Use Committee (IACUC) protocols and ensure compliance.
    • Analyze data from in vivo pharmacology and efficacy studies.
    • Contribute to study reports, potential regulatory filings, and project presentations.
    • Maintain excellent written documentation of completed experiments.

Who you are:

    • Ph.D. in Biology, Immunology, Pharmacology, or related fields with 0 - 5 years post graduate experience, or BSc with 5 plus year experience in industry
    • Extensive hands-on experience and familiarity with in vivo animal models, including manipulation, dosing, necropsy, and tissue dissociation.
    • Have experience working with tissue dissociation and ex vivo samples.
    • Have experience with multicolor flow cytometry.
    • mammalian cell culture, in vitro assay designs, and related cell/molecular biology methods is a plus.
    • Experience with multicolor and high dimensional flow cytometry is a plus.
    • Strong problem-solving, organization, and communication skills
    • Ability to work independently as well as part of a team.
    • Ability to adapt to a fast-paced environment and pivot to support ongoing needs.
Additional Requirements:
Full time in-person work is necessary for our laboratory-based positions. We work in facilities that require that all individuals working on-site are vaccinated for COVID-19. Position title and salary will be commensurate with experience.

We recognize the value of diversity in our workforce and are committed to building a welcoming and supportive working environment. We consider all qualified applicants without regard to race, religion, color, gender, age, national origin, sexual orientation, gender identity, partnership status, protected veteran status, disability, or any other status protected by federal, state, or local law. Individuals who hold legal work authorization applicable to employment in the United States will be considered without regard to citizenship/alienage.

We are not accepting unsolicited resumes from employment agencies for any employment opportunities at this time.