Scientist / Sr. Scientist

Cambridge, MA /
Research & Development – Assay Development /
Full Time
Company Overview
Proof Diagnostics is a start-up with a mission to provide direct access to premium, affordable, lab-quality molecular testing anytime, anywhere. Our user-friendly diagnostic system facilitates personalized healthcare, improving the health and safety of consumers everywhere by providing actionable health information. 

At Proof Diagnostics, we harness CRISPR-based technology to unlock powerful molecular diagnostic testing for all. Founded in 2020, by World-renowned CRISPR pioneer, Dr. Feng Zhang, of the Broad Institute of MIT and Harvard, Dr. Omar Abudayyeh and Dr. Jonathan Gootenberg, both McGovern Institute fellows at MIT, the company started with COVID-19, but plan to expand our platform to address broader healthcare challenges facing people worldwide. 
If you’re interested in creating lasting change at a mission driven company, come join our talented and growing team at Proof Diagnostics. With your help, we’ll push the boundaries of what’s possible in molecular diagnostics to build a better, safer world.
Position Summary
 Proof Diagnostics is seeking a Scientist/Senior Scientist focused on assay development. This role will design and develop molecular diagnostics assays utilizing our CRISPR-based technology. Efficiently design and execute experiments, perform appropriate statistical data analysis, and communicate results and observations effectively both as presentations and QMS-compliant documentation.

Responsibilities include, but are not limited to:

    • Innovate new chemistries for diagnostic applications from ideation to development.
    • Develop new assays using different clinical matrices and agents.
    • Conduct proof of concept and feasibility of different workflows to develop and improve our CRISPR assays.
    • Run hands-on experiments and work closely with other members of the team to conduct experiments for sample processing, nucleic acid amplification and CRISPR detection.
    • Conduct experimental design, data analysis using Excel, PRISM, JMP or similar, planning and execution of experiments to achieve company goals.
    • Responsible for ensuring the complete and accurate recording of all experiments and related reports and for maintaining the highest quality and integrity in our research.
    • Summarize, present data in internal or external meetings, author reports, write papers, etc.
    • Maintain excellent levels of housekeeping, safety, and environmental standards within the laboratory.
    • Provide day-to-day guidance and support in the lab for Research Associates.
    • Other duties as required.

Job Requirements and Necessary Skills:

    • PhD Degree in a relevant discipline (Infectious diseases, Molecular Biology, Molecular Microbiology, Biochemistry, etc.).
    • Post-graduate plus 3 to 5 years of industry experience and hands-on wet-lab and experimental design experience in the areas of molecular microbiology, virology (with focus on developing NAAT), or related field.
    • Hands-on knowledge of molecular biology with an emphasis in nucleic acid extraction, qPCR, RT-qPCR, primer and guide RNA design and troubleshooting. Experience with isothermal amplification technologies is desired.
    • Experience working in areas of infectious diseases, molecular biology, virology, bacteriology and working in a BSL2 environment is a plus.
    • Ability for critical thinking and troubleshooting to solve technical challenges.
    • Delivered publications and/or patents in academic and/or industry settings.
    • Excellent bench and data analysis skills.
    • Design of Experiments (DOE) is required.
    • Excellent written and verbal communication skills.
Proof Diagnostics offers excellent healthcare, dental, and vision benefits, as well as stock option compensation, a 401(k) program, and commuting reimbursement (where applicable). Proof Diagnostics is a fast-paced, high-growth company working diligently to make affordable and convenient molecular diagnostic testing accessible to everyone.
Proof Diagnostics values diversity and treats all employees and job applicants based on merit, qualifications, competence, and talent. Proof Diagnostics will not discriminate against any employee or applicant based on age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.