Senior Program Manager

Cambridge, MA /
Research & Development – Other /
Full Time
Company Overview
Proof Diagnostics is a start-up with a mission to provide direct access to premium, affordable, lab-quality
molecular testing anytime, anywhere. Our user-friendly diagnostic system facilitates personalized
healthcare, improving the health and safety of consumers everywhere by providing actionable health
information. 
At Proof Diagnostics, we harness CRISPR-based technology to unlock powerful molecular diagnostic
testing for all. Founded in 2020, by World-renowned CRISPR pioneer, Dr. Feng Zhang, of the Broad
Institute of MIT and Harvard, Dr. Omar Abudayyeh and Dr. Jonathan Gootenberg, both McGovern
Institute fellows at MIT, the company started with COVID-19, but plans to expand its platform to address
broader healthcare challenges facing people worldwide. 
If you’re interested in creating lasting change at a mission driven company, come join our talented and
growing team at Proof Diagnostics. With your help, we’ll push the boundaries of what’s possible in
molecular diagnostics to build a better, safer world.
Position Summary
The Senior Program Manager will be responsible for managing the execution of IVD development
programs that consist of multiple projects. Reporting to the CSO, the successful candidate will work
closely with members of the R&D team and supporting functions to achieve project goals, milestones,
and budget. The candidate will execute development programs from Concept through
Commercialization following Proof Diagnostics PDP Phase Gate process. He or She will organize the
various programs and activities to improve company efficiencies and build the milestones, timeline, and
budget associated with each research or development project.
Responsibilities include but are not limited to:
● Manage the execution of assay development, hardware and software development
workstreams.
● Collaborate cross-functionally to create, maintain, and execute overall project concept or scope,
functional plans, resources, budgets and timelines.
● Work with Quality to develop necessary development SOPs, templates and ensure completion
of project documentation in line with established SOPs
● Help improve project management processes including building out the templates, tools,
metrics, and dashboards to support development and monitor projects internally and externally
and improve organizational efficiency and effectiveness

The Pine Trees
Health story:
Our world is
always turning,
but in early
2020, it
swerved.
Professor Feng
Zhang, a world-
renowned
molecular
biologist
leading a
research lab at
the Broad
Institute of MIT
and Harvard, hit
pause on his
then-current
work and, along
with fellow
colleagues,
pivoted to
address our
emergent need:
the COVID-19
pandemic. 
Along with our
world class
team that is
fueled by an
insatiable urge
to solve difficult
problems, Dr.
Zhang founded
Pine Trees
Health to
develop a
cutting edge,
CRISPR-based
platform for
nucleic acid
detection that
has been
optimized for
ease of use,
speed and
performance.
Our first test
system --
designed to
detect COVID-
19 -- will enable
us to fulfill our
mission to
participate in
restoring a
degree of
normalcy to our
world.  Further,
our scalable
platform for
rapid, accurate,
convenient, and
affordable
infectious
disease
detection can
be applied to
address many
more problems
in healthcare. 
If this sounds
interesting,
come join our
talented and
growing team at
Pine Trees
Health.  With
your help, we
are excited to
pioneer and
push the
boundaries of
what is possible
in molecular
diagnostics.
Benefits:
20
total PTO
days*
7
paid holidays
401

(k)

Commute

r
eimbursemen
t policy

Medical

insurance
Dental
insurance
Vision
insurance

*15 vacation days;
5 sick days
Quote from
Leader [why is it
fun? Why does
this work
matter? matter?]

● Drive, track and ensure communication of project status updates and deliverables
● Identify needs for changes to plan, communicating changes and program risks to the team and
stakeholders. Facilitate tradeoff decisions and remove obstacles in response to perceived risks.
● Continuously analyze and manage risks to enable successful program execution.
● Schedule and lead phase gate reviews with Core Team and Product Steering Board.


Necessary Education and Skills
 Minimum of bachelor’s degree in science or bioengineering or similar and 7+ years of
experience in the biotech/diagnostic/medical device fields
 PMP certificate desired
 Direct experience developing IVD products, preferably in molecular diagnostics.
● Demonstrated understanding with FDA and CE-IVD regulated product development processes
and design controls.
● Able to develop project/program budget/timeline/scope, proficient with resource management,
resource scheduling, and budgets, develop plans and communicate proposals to leadership
 Familiar with molecular assay development and or CRISPR technologies, nucleic acid based
diagnostic principles and point of care diagnostic devices.
● Proficient with project planning/scheduling tools, including dependencies and critical path
determination.
● Ability to establish strong working relationships with the project team to motivate and empower
others, generate ownership, and establish commitment.
● Excellent written and communication skills