Senior Director, Head of Protein Sciences and Structural Biology
Boston, MA
Discovery – Structural Biology & Biophysics /
Full-Time /
Hybrid
Position Summary
We are seeking an exceptional and highly motivated leader for our protein sciences and structural biology group. This individual will play a critical role in advancing our pipeline of first-in-class drug candidates. The successful candidate will have a proven track record of success in small molecule drug discovery, a deep understanding of structural biology, biophysics, biochemistry and a passion for innovation.
Responsibilities
- Lead and mentor a high-performing team of scientists in small molecule discovery, structural biology and in biophysical and biochemical strategies to advance programs.
- Enable small molecule drug discovery, from hit identification through lead optimization.
- Design and implement strategies for structure-based drug design, including X-ray crystallography, cryo-EM, and other relevant structural biology techniques.
- Collaborate with in-silico team to integrate structural biology and biophysical data to maximally leverage our unique computational advantage.
- Establish robust screening funnels and compound flows with project teams.
- Collaborate closely with other groups, including computational chemistry, medicinal chemistry, biology, and DMPK to advance drug discovery programs.
- Work with a cross-functional team to assess druggability and propose screening strategies for new targets.
- Stay abreast of the latest advances in small molecule discovery and structural biology ensuring that we implement the appropriate new technologies to enhance the group's capabilities to progress our drug pipeline.
- Represent Psivant at scientific conferences and meetings as a leader in structure-based drug discovery grounded in a deep understanding of the physical principles that govern biology.
- Contribute to scientific publications and patent applications.
Requirements
- Ph.D. in biochemistry, structural biology, or a related field.
- Minimum 10 years of experience in small molecule drug discovery, with a strong emphasis on structural biology. A deeper understanding of biophysical and biochemical strategies to enable small molecule discovery is preferred.
- Demonstrated experience leading and managing drug discovery teams.
- Expertise in a wide range of structural biology and biophysical techniques, including X-ray crystallography, cryo-EM, and computational modeling.
- Strong understanding and application of medicinal chemistry principles to drug design.
- Excellent communication and interpersonal skills.
- Ability to thrive in a fast-paced and collaborative cross functional environment.
About Psivant
Psivant Therapeutics is creating better therapeutics through an integrated molecular design paradigm that leverages best-in-class physics-based and AI technologies honed through decades of research and innovation. Our focus is first-in-class inflammation and immunology (I&I) small molecule therapeutics. We have assembled a diverse team with extensive experience across disciplines ranging from physics and computer science to chemistry, biology, biochemistry, and structural biology. This continuum of complementary skills drives our scientific vision to deliver meaningful therapeutics to patients in need. We are patient-inspired, perseverant, synergistic, supportive, intrepid, and inclusive. If you’re passionate about advancing medicine in a fast-paced, innovative environment, and eager to contribute to a team that blends advanced computation with drug discovery, Psivant might be the perfect fit for you.
At Psivant, we are a lean, high-performing team dedicated to pushing boundaries and achieving growth—both personally and scientifically. We seek individuals who are smart, collaborative, and thrive in a dynamic, early-stage biotech environment. Individuals joining Psivant can look forward to the following:
· Competitive salary and benefits package including 401k match
· Opportunity to make a significant impact on the development of novel therapeutics.
· Work with a talented and passionate team of scientists
· Be a part of a cutting-edge company that is revolutionizing drug discovery.
Learn more about our story at https://psivant.com/company/our-story/.
